Comparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysis

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dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorAğalar, Canan
dc.contributor.authorAkalın, Şerife
dc.contributor.authorAlıcı, Özlem
dc.contributor.authorYılmaz, Hava
dc.date.accessioned2020-04-30T22:41:14Z
dc.date.available2020-04-30T22:41:14Z
dc.date.issued2015
dc.departmentDÜ, Rektörlük, Sağlık Araştırma ve Uygulama Merkezien_US
dc.descriptionbalkan, ilker inanc/0000-0002-8977-5931; altay, fatma aybala/0000-0002-7149-2968; Karabay, Oguz/0000-0003-0502-432X; Durdu, Bulent/0000-0002-0244-4006en_US
dc.descriptionWOS: 000349144300018en_US
dc.descriptionPubMed: 25821319en_US
dc.description.abstractObjectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.en_US
dc.identifier.doi10.4103/0253-7613.150383en_US
dc.identifier.endpage100en_US
dc.identifier.issn0253-7613
dc.identifier.issn1998-3751
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.4103/0253-7613.150383
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3150
dc.identifier.volume47en_US
dc.identifier.wosWOS:000349144300018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofIndian Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlood stream infectionen_US
dc.subjectcolistinen_US
dc.subjectmonotherapyen_US
dc.subjectmulti drug resistant Acinetobacter sppen_US
dc.titleComparison of colistin monotherapy and non-colistin combinations in the treatment of multi-drug resistant Acinetobacter spp. bloodstream infections: A Multicenter retrospective analysisen_US
dc.typeArticleen_US

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