The Effect of Continuous Positive Airway Pressure (CPAP) Therapy on Serum Caspase-3 Level in Patients with Obstructive Sleep Apnea (OSA)

Basit Öğe Kaydı
dc.authoridFATIH, DAVRAN/0000-0002-6086-6602en_US
dc.authoridYildiz Gulhan, Pinar/0000-0002-5347-2365en_US
dc.authorscopusid57846383000en_US
dc.authorscopusid6508042832en_US
dc.authorscopusid36468092600en_US
dc.authorscopusid57199508851en_US
dc.authorscopusid59010136600en_US
dc.contributor.authorKaypak, Mustafa Kemal
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorDavran, Fatih
dc.contributor.authorGulhan, Pinar Yildiz
dc.contributor.authorYuregir, Ugur
dc.date.accessioned2024-08-23T16:07:05Z
dc.date.available2024-08-23T16:07:05Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIntroductionIntermittent hypoxemia has an important role in the physiopathogenesis of obstructive sleep apnea (OSA) complications. Increased apoptosis due to intermittent hypoxemia may be an important clinical entity in OSA. In this study, we aimed to evaluate caspase-3 enzyme level, which is an indirect marker of increased apoptosis in patients with OSA and to evaluate the effect of OSA treatment with continuous positive airway pressure on caspase-3 enzyme level.Materials and methodsThis study included 141 consecutive patients admitted to the sleep-disordered breathing laboratory within 6 months. Caspase-3 was measured in routine blood samples obtained on the morning of polysomnography (PSG) performed at night. The compliance of the patients to CPAP treatment was evaluated and caspase-3 levels were checked again after treatment.ResultsA total of 141 patients, 39 females (27,7%) and 102 males (72,3%) were included in the study. The mean age of the patients was 49 +/- 12 years (min-17, max-77). According to PSG results, OSA was detected in 95.7% (135/141) of the cases. Mild OSA was 35 (24.8%), moderate OSA 39 (27.7%) and severe OSA 61 (43.3%) cases. Median caspase-3 enzyme levels were similar in men and women in the study group. There was no statistically significant difference in hemogram parameters and caspase-3 enzyme levels between the groups divided according to the presence and severity of OSA. It was determined that caspase-3 enzyme level did not change significantly after 3 months of CPAP treatment in OSA compared to pretreatment. Caspase-3 was found to have a negative correlation with both the percentage of daily use of CPAP therapy and the percentage of CPAP device use for more than 1 h per night. It was found that the control caspase-3 level decreased statistically significantly as the percentage of daily use of CPAP therapy increased (r = -0.397, p = 0.030). It was found that the control caspase-3 level decreased statistically significantly as the percentage of CPAP therapy use for more than 1 h per night increased (r = -0.411, p = 0.024).ConclusionThe results of this study did not reveal a relationship between the severity of OSA and caspase-3 levels. However, blood caspase-3 levels decreased as treatment compliance increased, suggesting that CPAP treatment may correct increased apoptosis in OSA. There is a need for more comprehensive studies on this issue.en_US
dc.identifier.doi10.1007/s11325-024-03039-8
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.pmid38683249en_US
dc.identifier.scopus2-s2.0-85191794666en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s11325-024-03039-8
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14485
dc.identifier.wosWOS:001209530900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive sleep apneaen_US
dc.subjectCaspase-3en_US
dc.subjectApoptosisen_US
dc.subjectIntermittent Hypoxemiaen_US
dc.subjectCPAPen_US
dc.subjectIntermittent Hypoxiaen_US
dc.subjectActivated Caspase-3en_US
dc.subjectCell Apoptosisen_US
dc.subjectExpressionen_US
dc.titleThe Effect of Continuous Positive Airway Pressure (CPAP) Therapy on Serum Caspase-3 Level in Patients with Obstructive Sleep Apnea (OSA)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu