Differences in hepatitis A seroprevalence among geographical regions in Turkey: a need for regional vaccination recommendations

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dc.contributor.authorCeyhan, Mehmet
dc.contributor.authorYıldırım, İnci
dc.contributor.authorKurt, Neşe
dc.contributor.authorUysal, Gülnar
dc.contributor.authorDikici, B.
dc.contributor.authorEcevit, Çiğdem Ömür
dc.contributor.authorÇelebi, Solmaz
dc.date.accessioned2020-05-01T09:11:25Z
dc.date.available2020-05-01T09:11:25Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptiondikici, bunyamin/0000-0001-7572-6525en_US
dc.descriptionWOS: 000258784400013en_US
dc.descriptionPubMed: 18837839en_US
dc.description.abstractHepatitis A is a worldwide vaccine-preventable infection. Recommendation of vaccination depends on the endemicity of the disease. The World Health Organization recommends universal hepatitis A vaccination in intermediate areas; however, there is no need of mass vaccination in high and low endemicity regions. Therefore, most of the countries are using a vaccination policy according to the endemicity characteristic representing the whole of the country. The endemicity of this infection varies due to sanitary and hygiene conditions and socioeconomic differences among the countries and in various regions of the same country. A sample of 1173 persons between the age of 0 and 91 years from nine randomly selected medical centres from five different geographical centres of Turkey were tested for the level of anti-hepatitis A virus (anti-HAV) immunoglobulin-G antibodies using an enzyme-linked immunosorbent assay. The overall prevalence of anti-HAV antibodies was 64.4% (1142/1173). While the rate of sero-positivity was over 80% in the 5-9 age group and more than 90% after 14 years of age in south-eastern and eastern regions, it was lower than 50% at the age of 5-9 years in central and western regions and remains under 80% in those areas. We conclude that the differences observed in HAV sero-positivity among various geographical regions in Turkey support a universal HAV immunization policy for children currently living in regions of intermediate endemicity.en_US
dc.description.sponsorshipClement Weinberger of Sanofi Pasteuren_US
dc.description.sponsorshipWriting support was provided by Clement Weinberger of Sanofi Pasteur.en_US
dc.identifier.doi10.1111/j.1365-2893.2008.01034.xen_US
dc.identifier.endpage72en_US
dc.identifier.issn1352-0504
dc.identifier.issn1365-2893
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2893.2008.01034.x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5579
dc.identifier.volume15en_US
dc.identifier.wosWOS:000258784400013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Viral Hepatitisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendemicityen_US
dc.subjectgeographical variationen_US
dc.subjecthepatitis A virusen_US
dc.subjectseroprevalenceen_US
dc.subjectvaccinationen_US
dc.titleDifferences in hepatitis A seroprevalence among geographical regions in Turkey: a need for regional vaccination recommendationsen_US
dc.typeArticleen_US

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