May primary empty sella turcica be a cause of isolated ACTH deficiency? A case report and the review of related literature

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dc.contributor.authorGülcan, Erim
dc.contributor.authorGülcan, Aynur
dc.contributor.authorTaşer, Figen
dc.contributor.authorKorkmaz, Uğur
dc.contributor.authorErbilen, Enver
dc.date.accessioned2020-04-30T23:19:06Z
dc.date.available2020-04-30T23:19:06Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000252066300006en_US
dc.descriptionPubMed: 18063931en_US
dc.description.abstractIsolated ACTH deficiency is an uncommon cause of secondary adrenocortical insufficiency and accompaniment with primary empty sella has been reported in several cases. We present a case of isolated ACTH deficiency associated with empty sella. A sixty-two year old woman was admitted to our endocrine clinic with complaints of weakness, fatigue, weight loss, nausea, vomiting, and lack of appetite for about one month. Physical examination indicated orthostatic hypotension and epigastric tenderness. Laboratory investigations revealed hypoglycemia, hyponatremia and anemia, in addition low plasma cortisole and ACTH levels. Serum cortisole responses to short and prolonged ACTH stimulation were tested and partial and accurate responses were obtained, respectively. Plasma ACTH and serum cortisole levels failed to respond after intravenous injection of human corticotropin releasing hormone. Other hypophysial hormone levels were within the normal reference ranges. Although cranial and abdominal computerized tomography images were evaluated as normal, cranial magnetic resonance imaging of the pituitary gland revealed 'primary empty sella turcica' Replacement therapy with methylprednisolon resulted in the improvement of hypoglycemia, hyponatremia and clinical symptoms. Based on these results, the patient was diagnosed as isolated ACTH deficiency and was scheduled for follow up by our outpatient clinic. Our report is consistent with other reports pointing out that primary empty sella may be responsible for pathogenesis of isolated ACTH deficiency.en_US
dc.identifier.endpage748en_US
dc.identifier.issn0172-780X
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage745en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3649
dc.identifier.volume28en_US
dc.identifier.wosWOS:000252066300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMaghira & Maas Publicationsen_US
dc.relation.ispartofNeuroendocrinology Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectisolated ACTH deficiencyen_US
dc.subjectprimary empty sella turcicaen_US
dc.titleMay primary empty sella turcica be a cause of isolated ACTH deficiency? A case report and the review of related literatureen_US
dc.typeReview Articleen_US

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