Utilisation of Carbon Quantum Dots from Hazelnut Husk for Folic Acid (FA) Detection: An Innovative Approach

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dc.authoridDemirci, Tuna/0000-0001-8933-4944
dc.contributor.authorCiritcioglu, Ali Arda
dc.contributor.authorElibol, Erdem
dc.contributor.authorGunaydin, Zehra
dc.contributor.authorDemirci, Tuna
dc.date.accessioned2025-10-11T20:48:45Z
dc.date.available2025-10-11T20:48:45Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractThis study presents the development of a carbon quantum dot (CQD)-based fluorescence sensor for the accurate quantification of Folic Acid (FA). CQDs were synthesized from hazelnut husk using a solvothermal method and functionalized with silver ions to create an off-state fluorescence system. Upon mixing FA solutions, prepared from pure water and pharmaceutical tablets, with phosphate-buffered saline (PBS) and off-state CQDs, fluorescence emission was restored (on-state) in a concentration-dependent manner when excited at 360 nm. A strong linear relationship was observed between FA concentration and fluorescence intensity, with an R-2 value of approximate to 0.994. The samples were categorized into low (0.0376-0.7533 mu M) and high (0.7533-7.533 mu M) concentration groups for improved accuracy, achieving mean percentage errors of 0.70% and 1.85%, respectively, at concentrations as low as 0.565 mu M. This CQD-based sensor demonstrated rapid, cost-effective, and highly sensitive detection capabilities, making it a promising alternative for FA quantification in biomedical and nutritional applications. Furthermore, the use of sustainable raw materials, such as hazelnut husk, highlights the eco-friendly and practical advantages of this method over conventional techniques.en_US
dc.identifier.doi10.1007/s10930-025-10249-w
dc.identifier.endpage296en_US
dc.identifier.issn1572-3887
dc.identifier.issn1875-8355
dc.identifier.issue3en_US
dc.identifier.pmid40056330en_US
dc.identifier.scopus2-s2.0-86000487696en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1007/s10930-025-10249-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22074
dc.identifier.volume44en_US
dc.identifier.wosWOS:001439521400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofProtein Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectCarbon quantum dotsen_US
dc.subjectFA detectionen_US
dc.subjectFluorescence sensorsen_US
dc.subjectHazelnut husken_US
dc.titleUtilisation of Carbon Quantum Dots from Hazelnut Husk for Folic Acid (FA) Detection: An Innovative Approachen_US
dc.typeArticleen_US

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