Evaluation of Choroidal Vascularity Index and Its Association with Disease Activity in Sjögren's Syndrome: An EDI-OCT-Based Study

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dc.contributor.authorEsen, Atilla
dc.contributor.authorTasci, Murat
dc.contributor.authorToprak, Guvenc
dc.contributor.authorOksar, Metin
dc.contributor.authorDogan, Umit
dc.date.accessioned2026-07-01T11:39:51Z
dc.date.available2026-07-01T11:39:51Z
dc.date.issued2025
dc.departmentDüzce Üniversitesi
dc.description.abstractBackground: Sjogren's syndrome (SS) is a chronic autoimmune disorder primarily affecting exocrine glands, although it may also involve multiple organs, including the eye. The choroid, the most vascularized ocular structure, is affected by systemic diseases. The choroidal vascularity index (CVI), a parameter that reflects vascular damage, decreases as vascular injury increases. Method: A total of 40 SS patients, aged 18-75 years, and 40 healthy controls were enrolled. Disease activity was assessed using the Sjogren's Syndrome Disease Activity Index (SSDAI); patients with an SSDAI score >= 5 were classified as having active disease, while those with scores <5 were considered in remission. Enhanced depth imaging optical coherence tomography (EDI-OCT) images were analyzed using ImageJ software to measure the luminal area (LA) and total choroidal area (TCA), with CVI calculated as the ratio LA/TCA. Results: SS patients exhibited significantly lower CVI values (mean: 0.62 +/- 0.04) compared to controls (mean: 0.69 +/- 0.02; p < 0.001). No significant correlation was found between CVI and SS disease activity as measured by the SSDAI. Additionally, CVI did not significantly differ with respect to gender, age, disease duration, anti-SS-A, anti-SS-B, or rheumatoid factor (RF) positivity. However, CVI was significantly lower in patients with positive antinuclear antibodies. In multivariable analysis, ANA positivity and CRP >= 5 mg/L were independently associated with lower CVI, whereas ESR showed no association with CVI. Conclusion: Our findings indicate that SS patients exhibit reduced CVI, reflecting ocular vascular involvement, which was not associated with disease activity. As a non-invasive method, CVI measurement may serve as a useful tool for assessing microvascular damage induced by inflammatory processes.
dc.identifier.doi10.1080/09273948.2025.2581184
dc.identifier.endpage2456
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue10
dc.identifier.orcid0000-0002-3187-4355
dc.identifier.orcid0000-0002-4635-5179
dc.identifier.pmid41217218
dc.identifier.scopus2-s2.0-105021521141
dc.identifier.scopusqualityQ1
dc.identifier.startpage2449
dc.identifier.urihttps://doi.org/10.1080/09273948.2025.2581184
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23508
dc.identifier.volume33
dc.identifier.wosWOS:001614269900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofOcular Immunology and Inflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260623
dc.subjectChoroidal Vascularity Index
dc.subjectDisease Activity Index
dc.subjectOcular Vascular Involvement
dc.subjectOptical Coherence Tomography
dc.subjectSjogren'S Syndrome
dc.titleEvaluation of Choroidal Vascularity Index and Its Association with Disease Activity in Sjögren's Syndrome: An EDI-OCT-Based Study
dc.typeArticle

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