Possible stochastic sex determination in Bursaphelenchus nematodes

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dc.authoridAntoshechkin, Igor/0000-0002-9934-3040
dc.authoridSun, Simo/0000-0003-0481-0468
dc.authoridHasegawa, Koichi/0000-0002-9968-8129
dc.authoridKikuchi, Taisei/0000-0003-2759-9167
dc.authoridDayı, Mehmet/0000-0002-5367-918X
dc.authoridSternberg, Paul/0000-0002-7699-0173
dc.authoridShinya, Ryoji/0000-0002-2450-3054
dc.authorwosidDayı, Mehmet/GQP-8056-2022
dc.contributor.authorShinya, Ryoji
dc.contributor.authorSun, Simo
dc.contributor.authorDayı, Mehmet
dc.contributor.authorTsai, Isheng Jason
dc.contributor.authorMiyama, Atsushi
dc.contributor.authorChen, Anthony Fu
dc.contributor.authorHasegawa, Koichi
dc.date.accessioned2023-07-26T11:50:43Z
dc.date.available2023-07-26T11:50:43Z
dc.date.issued2022
dc.departmentDÜ, Ormancılık Meslek Yüksekokulu, Ormancılık Bölümüen_US
dc.description.abstractSex determination mechanisms evolve surprisingly rapidly, yet little is known in the large nematode phylum other than for Caenorhabditis elegans, which relies on chromosomal XX-XO sex determination and a dosage compensation mechanism. Here we analyze by sex-specific genome sequencing and genetic analysis sex determination in two fungal feeding/plant-parasitic Bursaphelenchus nematodes and find that their sex differentiation is more likely triggered by random, epigenetic regulation than by more well-known mechanisms of chromosomal or environmental sex determination. There is no detectable difference in male and female chromosomes, nor any linkage to sexual phenotype. Moreover, the protein sets of these nematodes lack genes involved in X chromosome dosage counting or compensation. By contrast, our genetic screen for sex differentiation mutants identifies a Bursaphelenchus ortholog of tra-1, the major output of the C. elegans sex determination cascade. Nematode sex determination pathways might have evolved by bottom-up accretion from the most downstream regulator, tra-1. In most species, sex is determined by genetic or environmental factors. Here, the authors present evidence that sex determination in Bursaphelenchus nematodes is instead likely to be regulated by a random, epigenetic mechanism.en_US
dc.description.sponsorshipJSPS [JP19K15853, 19H03212]; JST PRESTO [JPMJPR17Q5]; JST CREST [JPMJCR18S7]; Howard Hughes Medical Institute; Grants-in-Aid for Scientific Research [19H03212] Funding Source: KAKENen_US
dc.description.sponsorshipWe sincerely thank Ms. Miwako Kobayashi, Meiji University, Dr. Sota Ozawa, FFPRI, and Akemi Yoshida, the University of Miyazaki for their technical assistance in maintaining mutant nematodes and sequencing. This study was funded by JSPS Grant-in-Aid for Early-Career Scientists JP19K15853 (to R.S.), JSPS Grants-in-Aid for Scientific Research (B) 19H03212 (to T.K.), JST PRESTO Grant Number JPMJPR17Q5 (to R.S.) and JST CREST Grant Number JPMJCR18S7 (to T.K.). P.W.S. was an Investigator with the Howard Hughes Medical Institute, which supported this work.en_US
dc.identifier.doi10.1038/s41467-022-30173-2
dc.identifier.issn2041-1723
dc.identifier.issue1en_US
dc.identifier.pmid35546147en_US
dc.identifier.scopus2-s2.0-85130007209en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41467-022-30173-2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12414
dc.identifier.volume13en_US
dc.identifier.wosWOS:000801822900031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDayı, Mehmet
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofNature Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectExpression Analysis; Determination Gene; Musca-Domestica; Evolution; Differentiation; Chromosome; Gametogenesis; Okinawaensis; Temperature; Mechanismsen_US
dc.titlePossible stochastic sex determination in Bursaphelenchus nematodesen_US
dc.typeArticleen_US

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