Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome

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dc.contributor.authorAkbaş, Türkay
dc.contributor.authorŞahin, İbrahim Ethem
dc.contributor.authorÖztürk, Ayhan
dc.date.accessioned2020-04-30T22:39:05Z
dc.date.available2020-04-30T22:39:05Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000444731800005en_US
dc.descriptionPubMed: 30132587en_US
dc.description.abstractIntroduction: Alterations in thyroid hormone levels occur in patients with acute neurological disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD). Material and methods: Eleven brain-dead patients were studied prospectively. Thyroid hormones were measured on admission to the intensive care unit, the day before BD diagnosis (BD before), and the day after BD diagnosis (BD day). Results: Thyroid stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations were found to be significantly low on admission, BD before, and BD day compared to age-matched healthy controls. TSH levels were shown to be increasing on BD day. Free thyroxine (fT4) levels were within normal limits in all cases except in one case having low fT4 levels with normal TSH levels. No statistically significant changes were encountered between admission thyroid hormone levels and BD-before and BD-day thyroid hormone levels. Six patients were on steroid therapy when BD-before blood samples were drawn, and no difference in thyroid hormone levels was encountered between steroid users and non-users. Correlation analysis showed a positive correlation between GCS and TSH, but a negative association between fT3 and APACHE II. Conclusion: We have shown that patients with BD have altered thyroid hormones days before BD diagnosis, and these alterations continue until the diagnosis of BD. The changes in thyroid hormones are compatible with non-thyroidal illness syndrome.en_US
dc.identifier.doi10.5603/EP.a2018.0056en_US
dc.identifier.endpage549en_US
dc.identifier.issn0423-104X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://doi.org/10.5603/EP.a2018.0056
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2593
dc.identifier.volume69en_US
dc.identifier.wosWOS:000444731800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbrain deathen_US
dc.subjectcritical illnessen_US
dc.subjecteuthyroid-sick syndromeen_US
dc.subjectneuroendocrine changesen_US
dc.titleAlterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndromeen_US
dc.typeArticleen_US

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