Pupillographic evaluation accompanying structural and functional assessment of the optic nerve in patients with Parkinson's disease

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dc.authoridMEYDAN, BAYRAM/0000-0002-7752-6516
dc.contributor.authorBozkurt, Erdinc
dc.contributor.authorMuhafiz, Ersin
dc.contributor.authorErdogan, Can Emre
dc.contributor.authorNizamogullari, Serif
dc.contributor.authorToprak, Guevenc
dc.contributor.authorMeydan, Bayram
dc.date.accessioned2025-10-11T20:48:09Z
dc.date.available2025-10-11T20:48:09Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground To evaluate static and dynamic pupillary functions, contrast sensitivity, and retinal nerve fiber layer (RNFL) thickness in patients with Parkinson's disease. Methods The study included 25 right eyes of patients with Parkinson's disease (mean age: 67.88 +/- 9.40 years) and 26 right eyes of age- and sex-matched healthy controls (mean age: 64.15 +/- 7.60 years). Following the measurement of visual acuity and intraocular pressure, the RNFL thickness of the right eye was assessed using optical coherence tomography (Optovue, Inc., Fremont, CA, USA), and contrast sensitivity was measured with the CSV-1000E (Vector Vision, Dayton, OH, USA). Following a 5-minute period of dark adaptation, both static and dynamic pupillographic parameters were assessed using the Sirius corneal topography device (Sirius, CSO, Florence, Italy). Results There was no statistically significant difference between the groups in terms of age and sex (p = 0.126 and p = 0.579, respectively). RNFL thickness in the superior, inferior, nasal, and temporal quadrants of the right eye were as follows for Parkinson's and control groups, respectively: 133.6 +/- 18.03 vs. 144.73 +/- 17.44 mu m (p = 0.03), 122.0 +/- 14.47 vs. 134.96 +/- 25.28 mu m (p = 0.031), 67.76 +/- 12.05 vs. 74.65 +/- 12.05 mu m (p = 0.047), and 66.36 +/- 8.72 vs. 72.77 +/- 14.0 mu m (p = 0.057). A statistically significant thinning was observed in all quadrants except the temporal quadrant in Parkinson's patients (Fig. 1). Contrast sensitivity was significantly lower in the Parkinson's group across all spatial frequencies compared to controls (p = 0.03, 0.01, < 0.01, and 0.02, respectively) (Fig. 2). Although pupil sizes were smaller in the Parkinson's group under scotopic, mesopic, and photopic conditions in static pupillography, the differences were not statistically significant (p > 0.05). Similarly, in dynamic pupillography, the pupil diameters at 0, 2, 4, 8, 12, and 16 s were smaller in the Parkinson's group, but no statistically significant differences were found between the groups (p > 0.05) (Fig. 3). Conclusions While a significant reduction in RNFL thickness and contrast sensitivity was observed in patients with Parkinson's disease, static and dynamic pupillographic parameters did not differ significantly between the groups. Therefore, the prognostic utility of pupillography in Parkinson's disease remains inconclusive and should be further investigated in larger and longitudinal studies.en_US
dc.identifier.doi10.1186/s12886-025-04219-0
dc.identifier.issn1471-2415
dc.identifier.issue1en_US
dc.identifier.pmid40629262en_US
dc.identifier.scopus2-s2.0-105010232902en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/s12886-025-04219-0
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21755
dc.identifier.volume25en_US
dc.identifier.wosWOS:001524686300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectParkinson's diseaseen_US
dc.subjectPupillographyen_US
dc.subjectContrast sensitivityen_US
dc.subjectRNFLen_US
dc.subjectVisual functionen_US
dc.subjectNeurodegenerationen_US
dc.titlePupillographic evaluation accompanying structural and functional assessment of the optic nerve in patients with Parkinson's diseaseen_US
dc.typeArticleen_US

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