Serum homocysteine levels in highway toll collectors and the relationship with intima-media thickness of the carotid artery

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dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorErdoğmuş, Beşir
dc.contributor.authorAlp, Hamit Hakan
dc.contributor.authorBilgin, Cahit
dc.contributor.authorArbak, Peri Meram
dc.contributor.authorYavuz, Özlem
dc.date.accessioned2020-04-30T23:31:52Z
dc.date.available2020-04-30T23:31:52Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionALP, Hamit Hakan/0000-0002-9202-4944en_US
dc.descriptionWOS: 000254702300007en_US
dc.description.abstractAim: A relationship between air pollution and increased intima-media thickness (IMT) has been recently reported, but its etiology is not yet well understood. We aimed to determine whether exposure to exhaust particles, which are important air pollutants, is associated with increased serum homocysteine (Hcy) levels and whether elevated Hcy levels are associated with increased IMT. Materials and Methods: Serum Hcy levels were measured by fluorometric high performance liquid chromatography in 65 male highway toll collectors (HTCs) and 43 healthy male volunteers. IMT was measured with Doppler sonography by an experienced radiologist. Results: Serum Hcy levels (14.5 +/- 4.9 mmol/L, P < 0.005) and IMT (0.757 +/- 0.18 mm, P < 0.001) were higher in the HTC group than in controls (12.0 +/- 2.8 mmol/L and 0.612 +/- 0.11 mm, respectively). A positive correlation was found between Hcy level and IMT both in the HTC group (r = 0.36; P < 0.005) and in the control group (r = 0.36; P < 0.05). Conclusions: Exposure to exhaust particles may cause an increase in oxidative stress because of an increase in serum Hcy levels, which consequently may lead to an increase in IMT. Nevertheless, further studies on the subject are needed before drawing a firm conclusion.en_US
dc.identifier.endpage137en_US
dc.identifier.issn1300-0144
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage133en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4506
dc.identifier.volume38en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthomocysteineen_US
dc.subjectexhaust particlesen_US
dc.subjectintima-media thicknessen_US
dc.subjectoxidative stressen_US
dc.subjecthighway toll collectorsen_US
dc.titleSerum homocysteine levels in highway toll collectors and the relationship with intima-media thickness of the carotid arteryen_US
dc.typeArticleen_US

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