Clinical and polysomnographic evaluation of sleep-related breathing disorders in patients with sarcoidosis

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dc.authoridAnnakkaya, Ali Nihat/0000-0002-7661-8830
dc.authoridyildiz gülhan, pinar/0000-0002-5347-2365
dc.authorwosidAnnakkaya, Ali Nihat/A-8741-2017
dc.authorwosidyildiz gülhan, pinar/AAW-3004-2020
dc.contributor.authorAtaoğlu, Özlem
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorArbak, Peri Meram
dc.contributor.authorYıldız Gülhan, Pınar
dc.contributor.authorElverişli, Mehmet Fatih
dc.date.accessioned2023-07-26T11:53:52Z
dc.date.available2023-07-26T11:53:52Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective This study aimed to evaluate the frequency of obstructive sleep apnea (OSA) in patients with sarcoidosis and related clinical factors. Materials and method Consecutive patients diagnosed with sarcoidosis in our clinic were evaluated for OSA risk during sleep using the Epworth Sleepiness Scale, Stanford Sleepiness Scale, Pittsburgh Sleep Quality Index, Berlin questionnaire, STOP and STOP-BANG questionnaires, and polysomnography (PSG). Results A total of 60 sarcoidosis patients (mean age: 50 +/- 11 years, 45 (75%) women) were included in the study. Polysomnography was performed in 54 cases and revealed the diagnosis of OSA in 70% (38/54) of the patients. The mean age was higher in patients with sarcoidosis and OSA (54 +/- 11 vs. 47 +/- 13, p = 0.041) and body mass index values were significantly higher as well (31.9 +/- 4.4 vs, 29.0 +/- 4.6 kg/m(2), p = 0.034). Polysomnography revealed a higher rate of OSA in patients with sarcoidosis who had high-risk scores in Pittsburgh Sleep Quality Index, STOP questionnaire, and STOP-BANG questionnaire (p = 0.024, p < 0.001, and p < 0.001, respectively). Based on polysomnography, OSA was detected in 39% (5/13) with stage 1 sarcoidosis, 78% (28/36) with stage 2, and in all cases (5/5) with stage 3. OSA frequency and apnea-hypopnea index (AHI) were determined to increase with advanced sarcoidosis stage (p = 0.003, p = 0.043, respectively). AHI was positively correlated with sarcoidosis stage (p = 0.003, r = 0.391). The prevalence of OSA was significantly higher in patients receiving treatment compared to treatment-naive patients (88% vs. 57%, p = 0.018). Multivariate logistic regression analysis revealed the stage of the disease (p = 0.026) to be the single independent risk factor associated with increased risk of OSA in patients with sarcoidosis. Conclusion High rates of OSA were detected in sarcoidosis, increasing with the advanced disease stage. The findings suggest that patients with sarcoidosis and advanced age, obesity, steroid treatment, and involvement of lung parenchyma (stages 2 and 3) should be evaluated for OSA risk. Further investigations are needed to establish the potential causes of the high prevalence of OSA in sarcoidosis.en_US
dc.identifier.doi10.1007/s11325-021-02513-x
dc.identifier.endpage1855en_US
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue4en_US
dc.identifier.pmid35099757en_US
dc.identifier.scopus2-s2.0-85123940198en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1847en_US
dc.identifier.urihttps://doi.org/10.1007/s11325-021-02513-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12636
dc.identifier.volume26en_US
dc.identifier.wosWOS:000750627700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAtaoğlu, Özlem
dc.institutionauthorAnnakkaya, Ali Nihat
dc.institutionauthorArbak, Peri Meram
dc.institutionauthorYıldız Gülhan, Pınar
dc.institutionauthorElverişli, Mehmet Fatih
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectSarcoidosis; Obstructive Sleep Apnea; Polysomnography; Sleep Questionnairesen_US
dc.subjectExcessive Daytime Sleepiness; Apnea; Involvement; Predictors; Fatigue; Volumeen_US
dc.titleClinical and polysomnographic evaluation of sleep-related breathing disorders in patients with sarcoidosisen_US
dc.typeArticleen_US

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