Uncoupling Systemic Inflammation from Body Mass Index: The Unseen Role of Visceral Adiposity and Metabolic Phenotypes-A Subgroup Analysis of the Nationwide OBREDI-TR Cohort

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dc.contributor.authorIssever, Kubilay
dc.contributor.authorOral, Alihan
dc.contributor.authorGenc, Ahmed Cihad
dc.contributor.authorSolmaz, Ihsan
dc.contributor.authorKoca, Nizameddin
dc.contributor.authorTopaloglu, Ulas Serkan
dc.contributor.authorUyar, Seyit
dc.date.accessioned2026-07-01T11:39:18Z
dc.date.available2026-07-01T11:39:18Z
dc.date.issued2026
dc.departmentDüzce Üniversitesi
dc.description.abstractObjectives: Although obesity is known to cause low-grade chronic inflammation, the extent to which body mass index (BMI) reflects this remains questionable. To investigate this, we classified a national obesity cohort by BMI and evaluated its association with complete blood count (CBC)-derived systemic inflammatory indices. Methods: This retrospective, multi-center study included 6499 adults from the OBREDI-TR cohort with available laboratory data. Patients were categorized by BMI into Class I (30.0-34.9 kg/m(2), n = 2751), Class II (35.0-39.9 kg/m(2), n = 1804), and Class III (>= 40.0 kg/m(2), n = 1944) obesity. We compared demographic, clinical, and laboratory parameters, especially in terms of CBC-derived inflammation parameters: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Results: The Class III group was younger (42.73 +/- 13.21 vs. 45.14 +/- 14.12 in Class I) and predominantly female (p < 0.001 for both). None of the evaluated inflammatory indices showed significant differences across the groups (NLR, p = 0.435; PLR, p = 0.141; LMR, p = 0.520; SII, p = 0.326; SIRI, p = 0.459). Interestingly, hypertension was less common in the Class III obesity group (49.0% vs. 53.5% in Class I, p = 0.009). Conclusions: The failure of increasing inflammatory indices to parallel BMI, creating a ceiling effect, reflects the inadequacy of BMI in determining inflammatory burden. Evaluating the inflammatory burden of obesity through visceral adiposity and metabolic phenotyping (metabolically healthy (MHO) vs. metabolically unhealthy obesity (MUO) rather than BMI will provide a more accurate basis for objective clinical evaluation and personalized treatment.
dc.identifier.doi10.3390/jcm15103794
dc.identifier.issn2077-0383
dc.identifier.issue10
dc.identifier.pmid42194754
dc.identifier.scopus2-s2.0-105041037837
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm15103794
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23228
dc.identifier.volume15
dc.identifier.wosWOS:001776427900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260623
dc.subject[Keyword Not Available]
dc.titleUncoupling Systemic Inflammation from Body Mass Index: The Unseen Role of Visceral Adiposity and Metabolic Phenotypes-A Subgroup Analysis of the Nationwide OBREDI-TR Cohort
dc.typeArticle

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