Correlation with Platelet Parameters and Genetic Markers of Thrombophilia Panel (Factor II g.20210G > A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, beta-Fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) in Ischemic Strokes

Basit Öğe Kaydı
dc.contributor.authorTaşdemir, Şener
dc.contributor.authorErdem, Haktan Bağış
dc.contributor.authorŞahin, İbrahim
dc.contributor.authorÖzel, Lütfi
dc.contributor.authorÖzdemir, Gökhan
dc.contributor.authorEröz, Recep
dc.contributor.authorTatar, Abdulgani
dc.date.accessioned2020-04-30T22:41:50Z
dc.date.available2020-04-30T22:41:50Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000377435300004en_US
dc.descriptionPubMed: 26951304en_US
dc.description.abstractAn important type of arterial thrombosis, ischemic stroke is associated with increased mortality risk, severe disability and life quality impairment. In this study, we analyzed mean platelet volume, platelet count values and genetic thrombophilia markers of patients who have ischemic stroke history and searched the relationship with genetic predisposition of ischemic strokes and platelet parameters. A retrospective, clinical trial was performed by reviewing the ischemic stroke history (except cryptogenic events) of 599 patients and 100 controls. The results of the genetic thrombophilia panel were used to classify the study group and control group into low and high risk for thrombophilia groups. The high-risk group included patients homozygous/heterozygous for Factor II g.20210G > A or Factor V Leiden mutations with/without any other polymorphism. The low-risk group included patients heterozygous or homozygous for MTHFR (C677T, A1298C), PAI-1, beta-fibrinogen, Factor XIIIA (V34L) and glycoprotein IIIa (L33P) polymorphisms or negative in terms of both mutations and polymorphisms. The results of study showed us that high-risk group mutations are important risk factors for ischemic stroke but low-risk group polymorphisms are not significant. According to platelet parameters, although there was a significant difference between MPV and PLT values of ischemic stroke and control group, thrombophilia mutations and polymorphisms have not a significant effect on MPV and PLT values in ischemic stroke patients.en_US
dc.identifier.doi10.1007/s12017-016-8386-xen_US
dc.identifier.endpage176en_US
dc.identifier.issn1535-1084
dc.identifier.issn1559-1174
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://doi.org/10.1007/s12017-016-8386-x
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3256
dc.identifier.volume18en_US
dc.identifier.wosWOS:000377435300004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofNeuromolecular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStrokeen_US
dc.subjectMean platelet volumeen_US
dc.subjectPlatelet counten_US
dc.subjectFactor II g.20210G > Aen_US
dc.subjectFactor V Leidenen_US
dc.subjectMTHFR (C677T, A1298C)en_US
dc.subjectPAI-1en_US
dc.subjectbeta-Fibrinogenen_US
dc.subjectFactor XIIIA (V34L)en_US
dc.subjectGlycoprotein IIIa (L33P)en_US
dc.titleCorrelation with Platelet Parameters and Genetic Markers of Thrombophilia Panel (Factor II g.20210G > A, Factor V Leiden, MTHFR (C677T, A1298C), PAI-1, beta-Fibrinogen, Factor XIIIA (V34L), Glycoprotein IIIa (L33P)) in Ischemic Strokesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
3256.pdf
Boyut:
936.56 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu