The Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variants

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dc.contributor.authorUyrum, Ebru
dc.contributor.authorBalbay, Öner Abidin
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorBalbay, Ege Güleç
dc.contributor.authorSılan, Fatma
dc.contributor.authorArbak, Peri Meram
dc.date.accessioned2020-04-30T23:34:17Z
dc.date.available2020-04-30T23:34:17Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAnnakkaya, Ali Nihat N/0000-0002-7661-8830; Balbay, Ege Gulec/0000-0002-1557-7019en_US
dc.descriptionWOS: 000351355200006en_US
dc.descriptionPubMed: 25613112en_US
dc.description.abstractBackground: Clinical and epidemiological studies indicate that obstructive sleep apnea syndrome (OSAS) has a strong genetic basis. Objectives: To investigate the apolipoprotein E (APOE) alleles as a genetic risk factor in OSAS. Methods: A total of 73 patients (37 male) were included. All underwent full-night polysomnography and were evaluated for APOE alleles. Results: The mean age was 51 +/- 12 years. Forty-two of the patients had OSAS. The APOE3 allele was found in 97.3% (71/73) of the study population. The most common APOE genotype was E3/E3 (55/73, 75.3%). Compared to the individuals with no APOE2 alleles (E3/E3, E3/E4), the individuals with at least one APOE2 allele (E2/E3, E2/E4) had a 9.37-fold greater OSAS risk (OR = 9.37, 95% CI 1.13-77.7, p = 0.019). The individuals with APOE2 alleles (E2/E3, E2/E4) compared to the individuals with only an E3/E3 allele genotype had a 10-fold greater OSAS risk (OR = 10.3, 95% CI 1.24-86.61, p = 0.0308). Compared to the individuals with no APOE4 alleles (E2/E3, E3/E3), the individuals with APOE4 alleles (E2/E4, E3/E4) had a high but insignificant risk for OSAS (OR = 2.9, 95% CI 0.55-15.05, p = 0.286). The individuals with APOE4 alleles (E2/E4, E3/E4) compared to APOE3 alleles (E3/E3) had an increased but insignificant risk for OSAS (OR = 3.62, 95% CI 0.96-19.05, p = 0.127). Conclusion: Specific APOE genotypes are associated with OSAS in a high-risk population. (C) 2015 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000369560en_US
dc.identifier.endpage200en_US
dc.identifier.issn0025-7931
dc.identifier.issn1423-0356
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.1159/000369560
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5137
dc.identifier.volume89en_US
dc.identifier.wosWOS:000351355200006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofRespirationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectApolipoprotein Een_US
dc.subjectGene polymorphismen_US
dc.titleThe Relationship between Obstructive Sleep Apnea Syndrome and Apolipoprotein E Genetic Variantsen_US
dc.typeArticleen_US

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