Serum 25-hydroxyvitamin D is associated with insulin resistance independently of obesity in children ages 5-17

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dc.authoridArslanoglu, Ilknur/0000-0002-4975-9718
dc.authorwosidGun, Emrah/AAO-8819-2021
dc.contributor.authorGun, Emrah
dc.contributor.authorUzun, Hakan
dc.contributor.authorBolu, Semih
dc.contributor.authorArslanoglu, Ilknur
dc.contributor.authorKocabay, Kenan
dc.date.accessioned2021-12-01T18:47:25Z
dc.date.available2021-12-01T18:47:25Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractAim: To determine the association of vitamin D with insulin resistance and obesity in children. Methods: A total of 92 obese and 58 non-obese children aged 5-17 years were evaluated. Data were collected related to anthropometric (weight, height), and biochemical parameters (fasting plasma glucose, serum insulin, serum 25-hydroxyvitamin D, lipid profile, vitamin B12, parathormone) and physical examination (blood pressure, acanthosis nigricans, stria, lipomastia). Insulin resistance (IR) was calculated using the homeostasis model assessment (HOMA). HOMA-IR = fasting insulin level (mu U/ml) x fasting glucose (mg/dL)/405. A HOMA-IR value >2.5 was defined as insulin resistance. Results: According to the US Endocrine Society classification, vitamin D deficiency (0-20 ng/ml) was determined at significantly higher rates in the obese group than in the control group (p < 0.001). The rate of subjects with a vitamin D level of 20-30 ng/ml was significantly lower in the obese group than in the control group (p < 0.001) Within the obese group a statistically significant difference was determined between the insulin resistant and non-insulin resistant groups in respect of serum 25-hydroxyvitamin D levels (p = 0.001) and vitamin B12 levels (p = 0.001). A significant negative correlation was determined between serum 25-hydroxyvitamin D and HOMA-IR (r=-0.256, p = 0.016) and insulin (r = -0.258, p = 0.015). The systolic blood pressure (p = 0.001) and diastolic blood pressure (p = 0.003) values were significantly different in the control and obese groups. A statistically significant difference was determined between the control and obese groups in terms of the levels of insulin, HOMA-IR, HbA1c, cortisol, LDL, total cholesterol, HDL, triglyceride, hemoglobin, MCV, MPV, and calcium. Conclusion: The prevalence of vitamin D deficiency was higher in obese children compared to normal weight and overweight children. Serum 25(OH)D levels showed a negative correlation with insulin and HOMA-IR. Serum 25(OH)D is associated with insulin resistance independently of obesity. (C) 2020 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.pcd.2020.06.006
dc.identifier.endpage46en_US
dc.identifier.issn1751-9918
dc.identifier.issn1878-0210
dc.identifier.issue6en_US
dc.identifier.pmid32616391en_US
dc.identifier.scopus2-s2.0-85087172099en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1016/j.pcd.2020.06.006
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10266
dc.identifier.volume14en_US
dc.identifier.wosWOS:000594532200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofPrimary Care Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject25(OH)Den_US
dc.subjectVitamin D deficiencyen_US
dc.subjectInsulin resistanceen_US
dc.subjectObesityen_US
dc.subjectChilden_US
dc.subjectVitamin-D Deficiencyen_US
dc.subjectBeta-Cell Functionen_US
dc.subjectHypovitaminosis-Den_US
dc.subjectMetabolic Syndromeen_US
dc.subjectHigh-Risken_US
dc.subjectAdolescentsen_US
dc.subjectEthnicityen_US
dc.subjectSensitivityen_US
dc.subjectPopulationen_US
dc.subjectGlycemiaen_US
dc.titleSerum 25-hydroxyvitamin D is associated with insulin resistance independently of obesity in children ages 5-17en_US
dc.typeArticleen_US

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