Novel α-N-heterocyclic thiosemicarbazone complexes: synthesis, characterization, and antimicrobial of properties investigation

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dc.contributor.authorNartop, Dilek
dc.contributor.authorOzkan, Elvan Hasanoglu
dc.contributor.authorOgutcu, Hatice
dc.contributor.authorYetim, Nurdan Kurnaz
dc.contributor.authorOzdemir, Inci
dc.date.accessioned2025-10-11T20:48:24Z
dc.date.available2025-10-11T20:48:24Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIn this paper, eight novel alpha-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the alpha-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects. In this paper, eight novel alpha-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via1H-NMR, IR, TGA, UV-Vis, molar conductance and magnetic susceptibility measurements.en_US
dc.description.sponsorshipDuzce University Scientific Research Project [2021.05.03.1215]en_US
dc.description.sponsorshipThis work was supported by the Duzce University Scientific Research Project (grant number: 2021.05.03.1215).en_US
dc.identifier.doi10.1039/d4ra04002c
dc.identifier.endpage29318en_US
dc.identifier.issn2046-2069
dc.identifier.issue40en_US
dc.identifier.pmid39285885en_US
dc.identifier.scopus2-s2.0-85204399815en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage29308en_US
dc.identifier.urihttps://doi.org/10.1039/d4ra04002c
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21904
dc.identifier.volume14en_US
dc.identifier.wosWOS:001313059900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.titleNovel α-N-heterocyclic thiosemicarbazone complexes: synthesis, characterization, and antimicrobial of properties investigationen_US
dc.typeArticleen_US

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