Thyroid Homeostasis After Bariatric Surgery in Obese Cases

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dc.authoridOnmez, Attila/0000-0002-7188-7388
dc.authorwosidOnmez, Attila/AAL-2984-2020
dc.contributor.authorGokosmanoglu, Feyzi
dc.contributor.authorAksoy, Erkan
dc.contributor.authorOnmez, Attila
dc.contributor.authorErgenc, Hasan
dc.contributor.authorTopkaya, Sibel
dc.date.accessioned2021-12-01T18:49:36Z
dc.date.available2021-12-01T18:49:36Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractBackground The aim of this study was to determine changes in thyroid hormones and morphology with weight loss after bariatric surgery in obese patients. Methods This prospective study was performed in our endocrinology and surgery clinic. Pre- and post-bariatric surgery thyroid function tests and thyroid ultrasonography parameters were compared. Results Four hundred seventy-two patients were included in the study. Mean weight loss after surgery was 30.7 +/- 5.1 kg. TSH levels decreased statistically significantly parallel with weight loss and decreased BMI (p = 0.025) after bariatric surgery. However, no statistically significant change was observed in fT4 or fT3 levels (p > 0.05). A significant increase in thyroid parenchyma echogenicity, correlated with weight loss and time elapsed since surgery, was detected at ultrasonography (US) grayscale histogram analysis compared with muscle echogenicity (p = 0.032). An increase in echogenicity was even detected in patients with isoechoic thyroid parenchyma before surgery. Fasting insulin and HOMA-IR levels decreased after surgery (p = 0.010 and p = 0.001, respectively). Patients were divided into three groups based on weight loss. In group 3, preoperative TSH of 4.1 +/- 0.7 decreased to 1.6 +/- 0.7 postoperatively (p = 0.001), while preoperative HOMA-IR of 4.9 +/- 1.9 decreased to 2.4 +/- 0.8 postoperatively (p = 0.001). Conclusions Obesity causes thyroid hormone resistance through a mechanism similar to insulin resistance and leads to an increase in TSH similar to hyperinsulinemia. Our findings show that echogenicity at thyroid US increases in line with weight loss following bariatric surgery.en_US
dc.identifier.doi10.1007/s11695-019-04151-5
dc.identifier.endpage278en_US
dc.identifier.issn0960-8923
dc.identifier.issn1708-0428
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85074052332en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage274en_US
dc.identifier.urihttps://doi.org/10.1007/s11695-019-04151-5
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10749
dc.identifier.volume30en_US
dc.identifier.wosWOS:000490203600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofObesity Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectBariatric surgeryen_US
dc.subjectThyroiden_US
dc.subjectThyroid echogenicityen_US
dc.subjectSleeve Gastrectomyen_US
dc.subjectAdipose-Tissueen_US
dc.subjectWeight-Lossen_US
dc.subjectMechanismsen_US
dc.titleThyroid Homeostasis After Bariatric Surgery in Obese Casesen_US
dc.typeArticleen_US

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