The Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections Versus the Concentrated Form

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dc.authorscopusid57200792036en_US
dc.authorscopusid55393222400en_US
dc.authorscopusid57209807407en_US
dc.authorscopusid6507031438en_US
dc.authorscopusid12788710100en_US
dc.authorscopusid23487820400en_US
dc.authorwosidErbil, Hakan/KBR-2468-2024en_US
dc.authorwosidBotsali, Ayşenur/A-1672-2018en_US
dc.contributor.authorBotsali, Aysenur
dc.contributor.authorErbil, Hakan
dc.contributor.authorEsme, Pelin
dc.contributor.authorGamsizkan, Mehmet
dc.contributor.authorAksoy, Ali Okan
dc.contributor.authorCaliskan, Ercan
dc.date.accessioned2024-08-23T16:04:19Z
dc.date.available2024-08-23T16:04:19Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractINTRODUCTION Biostimulation properties of diluted and hyperdiluted calcium hydroxylapatite (CaHA) injections have become increasingly popular. However, the existing data are insufficient to certify a particular dose-response pattern.OBJECTIVE To assess and compare the dermal stimulation potentials of different concentrations of CaHA injections.MATERIALS AND METHODS Two independent experiments (Experiment-1: constant injection volume vs Experiment-2: constant CaHA amount) included 4 study groups each, and these experimental groups were placed consecutively on the abdominal skin of a juvenile Yorkshire pig. Histopathological and immunohistochemical stainings were performed on punch biopsy materials collected 4 months after the injection day.RESULTS The fibroblast count significantly decreased upon dilution from 1:3 to 1:19 in experiment 1 (p = .000) but still higher than the control group. In experiment 1, the collagen density of the concentrated form was more elevated than the 1:19 dilution and the negative control groups (p = .034 and .000, respectively) but similar to the 1:3 dilution (p = .123). No significant difference was observed between the groups regarding collagen density with a standard amount of CaHA (0.2 mL, 30%) (p > .05).CONCLUSION Despite the efficacy being more pronounced till 1:3 dilution, hyperdiluted CaHA at any dilution ratio up to 1:19 can provide a higher fibroblast count than the negative control group.en_US
dc.description.sponsorshipBurgeon Aestheticsen_US
dc.description.sponsorshipThis studywas supported by a research grant from Burgeon Aesthetics.~~en_US
dc.identifier.doi10.1097/DSS.0000000000003874
dc.identifier.endpage876en_US
dc.identifier.issn1076-0512
dc.identifier.issn1524-4725
dc.identifier.issue9en_US
dc.identifier.pmid37399137en_US
dc.identifier.scopus2-s2.0-85169172580en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage871en_US
dc.identifier.urihttps://doi.org/10.1097/DSS.0000000000003874
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14165
dc.identifier.volume49en_US
dc.identifier.wosWOS:001058050200010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofDermatologic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeocollagenesisen_US
dc.titleThe Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections Versus the Concentrated Formen_US
dc.typeArticleen_US

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