Obstructive Sleep Apnea Syndrome in Adult Patients with Asthma
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Drunpp-Sarajevo
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective and Introduction: Previous epidemiological studies have shown respiratory system diseases and obstructive sleep apnea syndrome (OSAS) to be frequently concomitant, and co-occurrence of OSAS with respiratory system disease increased the severity and complications of underlying lung disease. It is known that symptoms associated with asthma are generally more severe at nights. Obesity is a common risk factor for two prevalent disorders, namely asthma and obstructive sleep apnea syndrome, which are commonly observed in the society and are important at both individual and social levels. Similarly, anatomical and functional abnormalities of the upper airways and gastroesophageal reflux are other associated factors. Moreover, since upper airways, which is the focus of physiopathology in OSAS, is an important area affected also in asthma, it leads to research evaluating possible interactions of these two diseases with a mutual pathway in etiology. The objective of this study was to investigate the prevalence of OSAS in patients with asthma and its effect on the severity and the management of asthma. Material and Methods: In this study, 50 consecutive adult asthma patients (35 female and 15 male) who applied to the Department of Chest Diseases and accepted to participate in the study, were included. All of these patients underwent full overnight polysomnography. Results: The overall prevalence of OSAS was 40% (moderate and severe OSAS: 16%) in asthma patients. However, no significant difference could be determined between OSAS prevalence, based on the asthma severity. OSAS was determined at rates of; 52.9% (9/17) in full control asthma patients, 40.9% (9/22) in those with partial control, and 18.2% (2/11) in patients with no control. As better control levels were provided for asthma, prevalence of OSAS increased, however the differences were not statistically significant (p=0.185). Between OSAS severity and asthma control level, a weak reverse correlation was determined (p=0.05, r=0.279). In all asthma patients with OSAS, snoring was present (negative predictive value 100%). In asthma patients with habitual snoring, witnessed apnea and daytime sleepiness symptoms, OSAS prevalence was significantly higher compared to those with no symptoms. As concomitance of major symptoms increased, OSAS prevalence also increased significantly (p<0.05). As neck circumference and body mass index of patients with asthma increased, apnea-hypopnea index and OSAS severity significantly increased (p<0.05). A significantly positive correlation was determined between triceps fat thickness and asthma severity (p=0.003, r=0.563). Conclusions: Compared to the regular population, among adult asthma patients, OSAS prevalence was much higher. Especially asthma patients who are obese and have wide neck circumference should be examined regarding OSAS symptoms. In the presence of major OSAS symptoms, polysomnographic examination should definitely be conducted. The lack of snoring can be an important criterion in the exclusion of OSAS in asthma. Further studies are necessary in order to produce concomitance, interaction and long-term results of these two diseases.
Açıklama
Annakkaya, Ali Nihat N/0000-0002-7661-8830; Balbay, Ege Gulec/0000-0002-1557-7019
WOS: 000300538400009
WOS: 000300538400009
Anahtar Kelimeler
asthma, sleep apnea, obesity, snoring, obstructive sleep apnea syndrome, OSAS
Kaynak
Healthmed
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
6
Sayı
1
