The role of incretins in gestational diabetes: a case-control study on the impact of obesity

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dc.authoridyilmaz, gamze/0000-0001-8021-7653;
dc.contributor.authorYurtcu, Engin
dc.contributor.authorKeyif, Betul
dc.contributor.authorYilmaz, Gamze
dc.contributor.authorErkilinc, Selcuk
dc.contributor.authorAkkaya, Hatice
dc.contributor.authorOzgu-Erdinc, A. Seval
dc.date.accessioned2025-10-11T20:48:04Z
dc.date.available2025-10-11T20:48:04Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground This study aimed to evaluate the role of serum Glucagon-Like Peptide-1 (GLP-1), Glucagon-Like Peptide-2 (GLP-2), and Glucose-Dependent Insulinotropic Polypeptide (GIP) levels in relation to obesity and gestational diabetes mellitus (GDM) in pregnancy. Methods A case-control study was conducted, including 96 pregnant women with singleton pregnancies who underwent the Oral Glucose Tolerance Test (OGTT) for GDM diagnosis during the 24th-28th weeks of gestation. Blood samples were collected for measuring GLP-1, GLP-2, GIP, and fasting glucose. Statistical analyses included receiver operating characteristic (ROC) curves and correlation analysis. Results Among the 96 women, no significant difference in age was observed between the groups, but Body Mass Index (BMI) was significantly higher in GDM-O (Gestational Diabetes Mellitus-Obese) and non-GDM-O groups (p < 0.001). GLP-1 had an area under the curve (AUC) of 0.666 (95% CI: 0.553-0.778, p = 0.005) for diagnosing GDM. The optimal GLP-1 cutoff was 815.86 ng/mL, with 65% sensitivity and 77% specificity. A significant correlation was found between GLP-2 and GIP (r = 0.289, p = 0.004), but no significant correlations were observed between GLP-1 and other peptides or gestational age (p > 0.05). Conclusions Impaired secretion of GLP-1, GLP-2, and GIP likely contributes to the pathogenesis of GDM. GLP-1 may serve as a potential biomarker for diagnosing GDM.en_US
dc.description.sponsorshipScientific Research Projects Coordination Office of Duzce University [2021.04.02.1261]en_US
dc.description.sponsorshipThe funding for this study has been provided by the Scientific Research Projects Coordination Office of Duzce University (grant No. 2021.04.02.1261).en_US
dc.identifier.doi10.1186/s13098-024-01483-w
dc.identifier.issn1758-5996
dc.identifier.issue1en_US
dc.identifier.pmid39420427en_US
dc.identifier.scopus2-s2.0-85206560887en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/s13098-024-01483-w
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21740
dc.identifier.volume16en_US
dc.identifier.wosWOS:001338954700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofDiabetology & Metabolic Syndromeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectGestational diabetes mellitusen_US
dc.subjectGLP-1en_US
dc.subjectGLP-2en_US
dc.subjectGIPen_US
dc.subjectIncretinen_US
dc.titleThe role of incretins in gestational diabetes: a case-control study on the impact of obesityen_US
dc.typeArticleen_US

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