Synthesis and antimicrobial evaluation of novel heterocyclic compounds containing thiosemicarbazone
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, six novel heterocyclic compounds containing thiosemicarbazone were obtained by the condensation reaction of thiazole with thiosemicarbazide and benzaldehyde derivatives. The structures of newly obtained thiosemicarbazone-based heterocyclic compounds were investigated by spectroscopic methods (element analysis, infrared spectra (IR), proton nuclear magnetic resonance (1H-NMR), high resolution mass spectrometry (HRMS), scanning electron microscopy and energy dispersive X-ray (SEM-EDX). The antimicrobial efficiency of the obtained thiosemicarbazone-based heterocyclic compounds was screened in vitro against some pathogenic bacteria and yeast as potential medicinal agents. New heterocyclic compounds containing thiosemicarbazone were determined to be effective in varying degrees at inhibiting the activity of the tested disease-causing pathogenic strains. The heterocyclic compounds were found to show high or moderate antimicrobial activity. It was found that the synthesized heterocyclic compounds showed high or moderate antimicrobial activity.
Açıklama
Anahtar Kelimeler
heterocyclic compounds, thiosemicarbazide, condensation reaction, antimicrobial activity
Kaynak
Main Group Chemistry
WoS Q Değeri
Q4
