Synthesis and antimicrobial evaluation of novel heterocyclic compounds containing thiosemicarbazone

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dc.contributor.authorMacit, Ahsen Zeynep
dc.contributor.authorNartop, Dilek
dc.contributor.authorOgutcu, Hatice
dc.date.accessioned2025-10-11T20:48:10Z
dc.date.available2025-10-11T20:48:10Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractHerein, six novel heterocyclic compounds containing thiosemicarbazone were obtained by the condensation reaction of thiazole with thiosemicarbazide and benzaldehyde derivatives. The structures of newly obtained thiosemicarbazone-based heterocyclic compounds were investigated by spectroscopic methods (element analysis, infrared spectra (IR), proton nuclear magnetic resonance (1H-NMR), high resolution mass spectrometry (HRMS), scanning electron microscopy and energy dispersive X-ray (SEM-EDX). The antimicrobial efficiency of the obtained thiosemicarbazone-based heterocyclic compounds was screened in vitro against some pathogenic bacteria and yeast as potential medicinal agents. New heterocyclic compounds containing thiosemicarbazone were determined to be effective in varying degrees at inhibiting the activity of the tested disease-causing pathogenic strains. The heterocyclic compounds were found to show high or moderate antimicrobial activity. It was found that the synthesized heterocyclic compounds showed high or moderate antimicrobial activity.en_US
dc.description.sponsorshipDuzce University Scientific Research Project [2021.05.03.1215]en_US
dc.description.sponsorshipThe authors disclosed receipt of the followingfinancial support forthe research, authorship, and/or publication of this article: Thestudy was supported by Duzce University Scientific Research Project (grant number: 2021.05.03.1215).en_US
dc.identifier.doi10.1177/10241221251380069
dc.identifier.issn1024-1221
dc.identifier.issn1745-1167
dc.identifier.urihttps://doi.org/10.1177/10241221251380069
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21770
dc.identifier.wosWOS:001579306000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofMain Group Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectheterocyclic compoundsen_US
dc.subjectthiosemicarbazideen_US
dc.subjectcondensation reactionen_US
dc.subjectantimicrobial activityen_US
dc.titleSynthesis and antimicrobial evaluation of novel heterocyclic compounds containing thiosemicarbazoneen_US
dc.typeArticleen_US

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