Retinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammation

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dc.contributor.authorSav, Nadide M.
dc.contributor.authorTeberik, Kuddusi
dc.date.accessioned2025-10-11T20:48:25Z
dc.date.available2025-10-11T20:48:25Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: In Familial Mediterranean Fever (FMF), acute-phase reactants rise during attacks, indicating active inflammation. However, subclinical inflammation-present even during remission-may contribute to organ damage, including ocular involvement. This study aimed to investigate the effects of subclinical chronic inflammation on ocular structures in children with FMF. Methods: The study involved 51 pediatric FMF patients in remission for at least three months and healthy controls. Spectral domain optical coherence tomography (SD-OCT) was used to measure intraocular pressure, axial length, peripapillary retinal nerve fiber layer (RNFL) thickness, central macular thickness, and subfoveal choroidal thickness. Results: Acute-phase reactant levels were significantly elevated in the FMF group (p < 0.001). Inferotemporal RNFL thickness was notably reduced (p = 0.008), along with central macular, subfoveal, nasal, and temporal choroidal thicknesses. A mild positive correlation was observed between proteinuria and axial length (r = 0.282, p = 0.045). Conclusion: Subclinical inflammation in FMF may lead to early structural changes in the eye, potentially progressing over time. These findings highlight the importance of long-term ophthalmologic monitoring in pediatric FMF patients to better understand the cumulative impact of persistent inflammation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUEBITAK)en_US
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUEBITAK).en_US
dc.identifier.doi10.1038/s41390-025-04195-7
dc.identifier.issn0031-3998
dc.identifier.issn1530-0447
dc.identifier.pmid40481291en_US
dc.identifier.scopus2-s2.0-105007699097en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41390-025-04195-7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21915
dc.identifier.wosWOS:001504228200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofPediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.titleRetinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammationen_US
dc.typeArticleen_US

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