May argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?

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dc.contributor.authorErtekin, Tolga
dc.contributor.authorBozkurt, Özlem
dc.contributor.authorEröz, Recep
dc.contributor.authorNisari, Mehtap
dc.contributor.authorBircan, Duygu
dc.contributor.authorNisari, Mustafa
dc.contributor.authorUnur, Erdoğan
dc.date.accessioned2020-04-30T23:19:06Z
dc.date.available2020-04-30T23:19:06Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000388707600006en_US
dc.descriptionPubMed: 28125891en_US
dc.description.abstractBACKGROUND: Rhamnetin is a flavonoid that has antioxidant, anti-inflammatory and anti-cancer effects. Nucleolar-organizing regions are the ribosomal genes region. We aimed to identify whether rhamnetin has an effect on cell proliferation and whether AgNOR proteins may be used for the detection of therapeutic benefits of the drugs and new metabolites, which have the potential of being used for cancer treatments. METHODS: Twenty-four mice with Ehrlich's ascites carcinoma (EAC) were randomly assigned to three main groups as positive control, and groups 2 and 3 treated intraperitoneally with rhamnetin (100 mu g/kg and 200 mu g/kg, respectively). All the animals were sacrificed on day 16, 24 h after the last dose; the tumors, which developed at the site of injection were removed. Then, mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were detected for each mouse. RESULTS: Significant differences were detected among all groups for mean AgNOR number (p = 0.000) and TAA/NA ratio (p = 0.000). While the difference between positive control and Rhamnetin (100 mu g/kg) group was not significant (p = 0.387), there are signifi cant differences between positive control and Rhamnetin (200 mu g/kg) group (p = 0.000) and between Rhamnetin (100 mu g/kg) and Rhamnetin (200 mu g/kg) groups (p = 0.000) for TAA/NA ratio. CONCLUSION: Rhamnetin has an important role in preventing cancer formation. Our study showed that mean AgNOR numbers and TAA/NA values may be used also as biomarkers for evaluating the success rate of the performed therapeutic strategy and accurate dose selection for the management of the disease (Tab. 3, Fig. 3, Ref. 45). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipErciyes UniversityErciyes University [EU-BAP- THD-2016-6499]en_US
dc.description.sponsorshipThis work was supported by Erciyes University (EU-BAP- THD-2016-6499).en_US
dc.identifier.doi10.4149/BLL_2016_126en_US
dc.identifier.endpage658en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_126
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3648
dc.identifier.volume117en_US
dc.identifier.wosWOS:000388707600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNORen_US
dc.subjectAgNORsen_US
dc.subjectrhamnetinen_US
dc.subjectcancer treatmentsen_US
dc.subjectrDNAen_US
dc.titleMay argyrophilic nucleolar organizing region-associated protein synthesis be used for selecting the most reliable dose of drugs such as rhamnetin in cancer treatments?en_US
dc.typeArticleen_US

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