Portal vein hemodynamics in patients with non-alcoholic fatty liver disease

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dc.contributor.authorErdoğmuş, Beşir
dc.contributor.authorTamer, Ali
dc.contributor.authorBüyükkaya, Ramazan
dc.contributor.authorYazıcı, Burhan
dc.contributor.authorBüyükkaya, Ayla
dc.contributor.authorKorkut, Esin
dc.contributor.authorKorkmaz, Uğur
dc.date.accessioned2020-04-30T23:21:07Z
dc.date.available2020-04-30T23:21:07Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAlcelik, Aytekin/0000-0002-3156-1076en_US
dc.descriptionWOS: 000256508900010en_US
dc.descriptionPubMed: 18509239en_US
dc.description.abstractParalleling the rise in the incidence of obesity and diabetes worldwide, nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as one of the major causes of chronic liver disease. Doppler sonography is used as a diagnostic method in the non-invasive assessment of the hemodynamics of hepatic vascular flow in liver diseases. We investigated the effects of fatty infiltration in the liver on the Doppler flow hemodynamics of the portal vein. Doppler sonography of the liver and portal vein was performed in 60 subjects with NAFLD and 20 healthy volunteers (control). The patients were grouped into mild (grade 1), moderate (grade 2), and severe (grade 3) according to sonographic appearance of hepatosteatosis (n = 20 for each group). The vein pulsatility index (VPI), mean flow velocity (MFV), peak maximum velocity (V-max), and peak minimum velocity (V-min) of the portal vein were significantly lower in patients with NAFLD than those of the controls (p < 0.001). The VPI was 0.20 in the patients and 0.31 in the control. The MFV was 12.3 cm/sec in the patients and 16.5 cm/sec in the control group. The portal vein flow was found to be decreased as the grade of fatty infiltration increased for VPI (r = -0.946, p < 0.001),MFV(r=-0.951,p < 0.001). The alteration in Doppler waveform pattern of portal vein with fatty liver population suggests reduced vascular compliance in the liver.en_US
dc.identifier.doi10.1620/tjem.215.89en_US
dc.identifier.endpage93en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.215.89
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4140
dc.identifier.volume215en_US
dc.identifier.wosWOS:000256508900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal Of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDoppler sonographyen_US
dc.subjectnonalcoholic fatty liveren_US
dc.subjectportal vein pulsatilityen_US
dc.subjecthepatosteatosisen_US
dc.subjectliveren_US
dc.titlePortal vein hemodynamics in patients with non-alcoholic fatty liver diseaseen_US
dc.typeArticleen_US

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