Iloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemia-reperfusion in rats

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dc.contributor.authorGedik, Ercan
dc.contributor.authorGirgin, Sadullah
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2020-04-30T13:32:34Z
dc.date.available2020-04-30T13:32:34Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 19504007en_US
dc.description.abstractPurpose: To evaluate the effects of iloprost a prostacyclin analogue on the hepatic IR injury in rats. Methods: Forty male Sprague-Dawley rats (250-300 g) were divided into four groups each containing 10 rats; - (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats that underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/ Iloprost group: rats pretreated with iloprost (10 ?g kg-1, i.v). Liver tissues were taken to determine SOD, CAT, GSH, and MDA levels and for biochemical and histological evaluation. Results: The plasma ALT and AST levels were increased in group 3 than in group 4. MDA values and the liver injury score decreased, while the SOD, CAT, and GSH values increased in group 4 compared to group 3. In group 3, hepatocytes were swollen with marked vacuolization. In group 4, there were regular sinusoidal structures with normal morphology without any signs of congestion. Conclusion: We demonstrated hepatoprotective effects of iloprost against severe ischemia and reperfusion injury in rat liver.en_US
dc.identifier.doi10.1590/S0102-86502009000300012en_US
dc.identifier.endpage232en_US
dc.identifier.issn0102-8650
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage226en_US
dc.identifier.urihttps://dx.doi.org/10.1590/S0102-86502009000300012
dc.identifier.urihttps://hdl.handle.net/20.500.12684/352
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIloprost; Ischemia; Liver; Rats; Reperfusionen_US
dc.titleIloprost, a prostacyclin (PGI2) analogue, reduces liver injury in hepatic ischemia-reperfusion in ratsen_US
dc.typeArticleen_US

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