Time-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocks

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dc.contributor.authorCoşkun, Nuri Cenk
dc.contributor.authorUsanmaz, Suzan Emel
dc.contributor.authorSavcı, Vahide
dc.contributor.authorYılmaz, Emine Demirel
dc.date.accessioned2020-04-30T23:34:49Z
dc.date.available2020-04-30T23:34:49Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionDemirel-Yilmaz, Emine/0000-0002-2476-6225; Usanmaz, Suzan E./0000-0002-7096-1347en_US
dc.descriptionWOS: 000419896200004en_US
dc.descriptionPubMed: 29019070en_US
dc.description.abstractShock is associated with inflammation-induced endothelial dysfunction. The aim of this study was to determine time-dependent alteration of blood biomarkers related to endothelial function in hemorrhagic and septic shocks. Hemorrhagic shock was induced by bleeding the animals. A cecal ligation and incision model was used to induce septicemia. Resuscitation was carried out by infusion of lactated Ringer's solution. Resuscitation extended survival time in both shock groups. Blood pressure increased by resuscitation in the hemorrhagic shock but not in the septic shock. While hemorrhage caused a decrease in plasma levels of nitric oxide (NO) and hydrogen sulfide (H2S), asymmetric dimethylarginine (ADMA) and total antioxidant capacity (TAC) levels were increased. Only NO and TAC levels at the late phase were reversed by resuscitation. On the other hand, plasma levels of NO, ADMA, and TAC were increased by septicemia and resuscitation did not alter the septicemia-induced increase. These results indicate that blood biomarkers related to endothelial function were differentially affected by hemorrhage and septicemia. The time scale of biomarker production should be taken into consideration for the diagnostic and therapeutic approaches to these life-threatening diseases.en_US
dc.description.sponsorshipCommission of the Scientific Research Projects of Uludag UniversityUludag University [2008/43]en_US
dc.description.sponsorshipThe present study was supported by a grant from The Commission of the Scientific Research Projects of Uludag University (2008/43). We are grateful to Soner Mamuk for the great technical assistance.en_US
dc.identifier.doi10.1007/s10753-017-0660-zen_US
dc.identifier.endpage41en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-017-0660-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5229
dc.identifier.volume41en_US
dc.identifier.wosWOS:000419896200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthemorrhagic shocken_US
dc.subjectseptic shocksen_US
dc.subjectNOen_US
dc.subjectADMAen_US
dc.subjectTACen_US
dc.subjectH2Sen_US
dc.titleTime-Dependent Production of Endothelium-Related Biomarkers is Affected Differently in Hemorrhagic and Septic Shocksen_US
dc.typeArticleen_US

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