Investigation of Vitamin B12 Deficiency in Patients with Acute Coronary Syndrome and its Relationship with Gensini Score

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dc.authoridpolat, esra/0000-0002-2330-2816
dc.authorwosidpolat, esra/GNW-6743-2022
dc.contributor.authorPolat, Esra
dc.contributor.authorDemir, Mehmet Cihat
dc.contributor.authorKüçükdemirci, Ömer
dc.date.accessioned2023-07-26T11:57:22Z
dc.date.available2023-07-26T11:57:22Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalıen_US
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractBackground: Vitamin B12 deficiency is not an independent risk factor for cardiovascular disease. However, anemia due to vitamin B12 deficiency and also hyperhomocysteinemia are among the cardiovascular risk factors. The study aimed to determine the frequency of vitamin B12 deficiency in patients with acute coronary syndrome. We also aimed to ascertain whether there is a significant difference between obstructive coronary artery disease presence and its severity in patients with and without vitamin B12 deficiency using the Gensini score. Methods: Patients who underwent coronary angiography due to acute coronary syndrome between June 1, 2018, and November 30, 2019, and whose vitamin B12 levels were measured were retrospectively analyzed. Coronary angiography results of the patients were evaluated with the Gensini scoring system. Results: Anemia was observed in 32.6% (n = 135) of the patients who underwent coronary angiography with a diagnosis of acute coronary syndrome, and vitamin B12 deficiency was observed in 14.7% (n = 61). The median age was 69 years in anemic patients and 68 years in those with Vitamin B12 deficiency and was significantly higher than patients without anemia and vitamin B12 deficiency (p < 0.001 and p = 0.038, respectively). There was no statistically significant differences between the patients' Gensini scores with or without Vitamin B12 deficiency (p = 0.554). Conclusions: We concluded that anemia and vitamin B12 deficiency were higher in elderly patients with acute coronary syndrome. We found no significant difference when the Gensini score was used to evaluate obstructive coronary artery disease presence and its severity according to anemia and vitamin B12 deficiency. Investigating vitamin B12 levels in elderly patients with acute coronary syndrome should not be ignored.en_US
dc.identifier.doi10.7754/Clin.Lab.2021.210513
dc.identifier.endpage313en_US
dc.identifier.issn1433-6510
dc.identifier.issue2en_US
dc.identifier.pmid35142189en_US
dc.identifier.scopus2-s2.0-85124260188en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage307en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2021.210513
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13152
dc.identifier.volume68en_US
dc.identifier.wosWOS:000745788200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDemir, Mehmet Cihat
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAcute Coronary Syndrome; Anemia; Gensini Score; Vitamin B12 Deficiencyen_US
dc.subjectCobalamin; Anemiaen_US
dc.titleInvestigation of Vitamin B12 Deficiency in Patients with Acute Coronary Syndrome and its Relationship with Gensini Scoreen_US
dc.typeArticleen_US

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