Autoimmune encephalitis and paraneoplastic syndromes in Turkey: a multi-centre study

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dc.authoridPAZARCI, Nevin/0000-0002-3004-3031
dc.authoridYıldırım, Zerrin/0000-0002-5128-1784
dc.authoridSURMELI, Reyhan/0000-0002-0215-0614
dc.authoridBastug Gul, Zeynep/0000-0002-3256-5394
dc.authoridAtaklı, Hayrunisa Dilek/0000-0001-6458-8374
dc.authoridÇelik, Havva Tuğba/0000-0003-0893-8389
dc.authoridOzgenc Bicer, Cisil Irem/0000-0002-4582-3495
dc.authorwosidAtmaca, MM/AGB-2783-2022
dc.authorwosidPAZARCI, Nevin/HJZ-3822-2023
dc.authorwosidYıldırım, Zerrin/M-5053-2019
dc.authorwosidŞen, Aysu/HLH-6344-2023
dc.authorwosidSURMELI, Reyhan/HOF-3423-2023
dc.authorwosidBastug Gul, Zeynep/AAD-1027-2022
dc.authorwosidYaman, Aylin/HKV-3551-2023
dc.contributor.authorGözübatık-Çelik, Rabia Gökçen
dc.contributor.authorGÜl, Zeynep Baştuğ
dc.contributor.authorBilgin, Elif Bengisu
dc.contributor.authorYıldız, Mina Üzülmez
dc.contributor.authorYenidunya, Onur
dc.contributor.authorMısırlı, Handan
dc.contributor.authorÇelik, Havva Tuğba
dc.date.accessioned2023-07-26T11:50:34Z
dc.date.available2023-07-26T11:50:34Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Autoimmune encephalitis (AIE) and paraneoplastic syndromes (PNS) are both rare groups of neurological diseases that are difficult to diagnose. Aim We aimed to determine the common and distinct aspects of these two aetiologies of encephalitis as well as the characteristics of our patient group. Methods We respectively analysed the records of the patients including symptoms, demographic features, neurological examination, cranial-magnetic-resonance-imaging (MRI), electroencephalography (EEG) findings, cerebrospinal fluid results (CSF) findings. Autoimmune/paraneoplastic autoantibodies in blood and/or CSF were all documented. Results Forty-six patients fulfilled the diagnostic criteria. Thirty-eight of them were diagnosed with AIE, and 8 of them were diagnosed with PNS. The PNS group had higher nonconvulsive status epilepticus than the AIE (2/8 vs 0/38; p=0.027). PNS patients were diagnosed with a malignancy in their follow-ups more than those in the AIE group [4/38 vs 8/8] (p<0.001). When the symptoms of antibody-positive and negative patients were compared in the AIE group, the rates of consciousness/memory problems (13/15 vs 11/23; p=0.020) and speech impairment (8/15 vs 2/23; p=0.004) were significantly higher in patients without antibodies (n: 15) than in antibody-positive patients (n: 23). In antibody-negative groups, the rates of memory problems in neurological examination (13/15 vs 12/23 p=0.028) and temporal findings on electroencephalography were more prominent than antibody-positive groups (1/23 vs 5/15; p=0.027). The number of patients with cerebellar signs was higher in antibody-positive patients (6/23 vs 0/15; p=0.038). Conclusion Although the positivity of autoantibodies is critical in the diagnosis of AIE and PNS, even minor differences in clinical and laboratory findings of patients are helpful in the diagnosis, especially in the autoantibody-negative patients. Comparing the data with other population studies has shown that several inherited and environmental factors may contribute to the pathophysiology of AIE and PNS, as well as clinical and laboratory differences.en_US
dc.identifier.doi10.1007/s10072-022-05955-7
dc.identifier.endpage4403en_US
dc.identifier.issn1590-1874
dc.identifier.issn1590-3478
dc.identifier.issue7en_US
dc.identifier.pmid35211811en_US
dc.identifier.scopus2-s2.0-85125134358en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4393en_US
dc.identifier.urihttps://doi.org/10.1007/s10072-022-05955-7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12379
dc.identifier.volume43en_US
dc.identifier.wosWOS:000760704500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSungur, Mehmet Ali
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofNeurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAutoimmune Encephalitis; Paraneoplastic Syndromes; Antibodies; Clinical Featuresen_US
dc.subjectReceptor Antibodies; Autoantibodies; Lgi1en_US
dc.titleAutoimmune encephalitis and paraneoplastic syndromes in Turkey: a multi-centre studyen_US
dc.typeArticleen_US

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