Development and validation of a modified quick SOFA scale for risk assessment in sepsis syndrome

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dc.contributor.authorÇağ, Yasemin
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorSipahi, Oğuz Reşat
dc.contributor.authorAksoy, Firdevs
dc.contributor.authorDurmuş, Gül
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorVahaboğlu, Haluk
dc.date.accessioned2020-05-01T09:11:23Z
dc.date.available2020-05-01T09:11:23Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKarasu, Derya/0000-0003-1867-9018; Tufan, Zeliha Kocak/0000-0002-3294-014X; atilla, aynur/0000-0001-8027-1991; VAHABOGLU, Haluk/0000-0001-8217-1767; Cag, Yasemin/0000-0002-9983-0308en_US
dc.descriptionWOS: 000446000200057en_US
dc.descriptionPubMed: 30256855en_US
dc.description.abstractSepsis is a severe clinical syndrome owing to its high mortality. Quick Sequential Organ Failure Assessment (qSOFA) score has been proposed for the prediction of fatal outcomes in sepsis syndrome in emergency departments. Due to the low predictive performance of the qSOFA score, we propose a modification to the score by adding age. We conducted a multicenter, retrospective cohort study among regional referral centers from various regions of the country. Participants recruited data of patients admitted to emergency departments and obtained a diagnosis of sepsis syndrome. Crude in-hospital mortality was the primary endpoint. A generalized mixed-effects model with random intercepts produced estimates for adverse outcomes. Model-based recursive partitioning demonstrated the effects and thresholds of significant covariates. Scores were internally validated. The H measure compared performances of scores. A total of 580 patients from 22 centers were included for further analysis. Stages of sepsis, age, time to antibiotics, and administration of carbapenem for empirical treatment were entered the final model. Among these, severe sepsis (OR, 4.40; CIs, 2.35-8.21), septic shock (OR, 8.78; CIs, 4.37-17.66), age (OR, 1.03; CIs, 1.02-1.05) and time to antibiotics (OR, 1.05; CIs, 1.01-1.10) were significantly associated with fatal outcomes. A decision tree demonstrated the thresholds for age. We modified the quick Sequential Organ Failure Assessment (mod-qSOFA) score by adding age (> 50 years old = one point) and compared this to the conventional score. H-measures for qSOFA and mod-qSOFA were found to be 0.11 and 0.14, respectively, whereas AUCs of both scores were 0.64. We propose the use of the modified qSOFA score for early risk assessment among sepsis patients for improved triage and management of this fatal syndrome.en_US
dc.identifier.doi10.1371/journal.pone.0204608en_US
dc.identifier.issn1932-6203
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0204608
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5559
dc.identifier.volume13en_US
dc.identifier.wosWOS:000446000200057en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleDevelopment and validation of a modified quick SOFA scale for risk assessment in sepsis syndromeen_US
dc.typeArticleen_US

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