Characteristics and outcomes of patients with chronic obstructive pulmonary disease admitted to the intensive care unit due to acute hypercapnic respiratory failure

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dc.authoridAkbas, Turkay/0000-0002-2150-6866en_US
dc.authoridGunes, Harun/0000-0003-4899-828Xen_US
dc.authorscopusid22133297600en_US
dc.authorscopusid36159707800en_US
dc.authorwosidGüneş, Harun/AAE-8688-2020en_US
dc.authorwosidAkbas, Turkay/G-4609-2016en_US
dc.contributor.authorAkbas, Turkay
dc.contributor.authorGunes, Harun
dc.date.accessioned2024-08-23T16:03:27Z
dc.date.available2024-08-23T16:03:27Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: The study aimed to describe the clinical course, outcomes, and prognostic factors of chronic obstructive pulmonary disease (COPD) patients with acute hypercapnic respiratory failure. Methods: This retrospective study involved patients with acute hypercapnic respiratory failure due to COPD of any cause admitted to the intensive care unit (ICU) for non-invasive or invasive mechanical ventilation (IMV) support between December 2015 and February 2020. Results: One hundred patients were evaluated. The main causes of acute hypercapnic respiratory failure were bronchitis, pneumonia, and heart failure. The patients' mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 23.0 +/- 7.2, and their IMV rate was 43%. ICU, in-hospital, and 90-day mortality rates were 21%, 29%, and 39%, respectively. Non-survivors had more pneumonia, shock within the first 24 hours of admission, IMV, vasopressor use, and renal replacement therapy, along with higher APACHE II scores, lower admission albumin levels and PaO2/FiO(2) ratios, and longer ICU and hospital stays than survivors. Logistic regression analysis identified APACHE II score (odds ratio [OR], 1.157; 95% confidence interval [CI], 1.017-1.317; P=0.026), admission PaO2/FiO(2) ratio (OR, 0.989; 95% CI, 0.978-0.999; P=0.046), and vasopressor use (OR, 8.827; 95% CI, 1.650-47.215; P=0.011) as predictors of ICU mortality. APACHE II score (OR, 1.099; 95% CI, 1.021-1.182; P=0.011) and admission albumin level (OR, 0.169; 95% CI, 0.056-0.514; P=0.002) emerged as predictors of 90-day mortality. Conclusions: APACHE II scores, the PaO2/FiO(2) ratio, vasopressor use, and albumin levels are significant short-term mortality predictors in severely ill COPD patients with acute hypercapnic respiratory failure.en_US
dc.identifier.doi10.4266/acc.2022.01011
dc.identifier.endpage56en_US
dc.identifier.issn2586-6052
dc.identifier.issn2586-6060
dc.identifier.issue1en_US
dc.identifier.pmid36935534en_US
dc.identifier.scopus2-s2.0-85152206389en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.4266/acc.2022.01011
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13764
dc.identifier.volume38en_US
dc.identifier.wosWOS:001055365700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Soc Critical Care Medicineen_US
dc.relation.ispartofAcute And Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacute hypercapnic respiratory failureen_US
dc.subjectchronic obstructive pulmonary disease exacerbationen_US
dc.subjectmechanical ventilationen_US
dc.subjectmortalityen_US
dc.subjectPaO2/FiO(2) ratioen_US
dc.subjectAcute Exacerbationen_US
dc.subjectMortalityen_US
dc.subjectIcuen_US
dc.subjectPredictorsen_US
dc.subjectCopden_US
dc.subjectDiagnosisen_US
dc.titleCharacteristics and outcomes of patients with chronic obstructive pulmonary disease admitted to the intensive care unit due to acute hypercapnic respiratory failureen_US
dc.typeArticleen_US

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