Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder

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dc.contributor.authorAğartan, Aldırmaz Canan
dc.contributor.authorLeggett, Robert E.
dc.contributor.authorKogan, Barry A.
dc.contributor.authorLevin, Robert M.
dc.date.accessioned2020-04-30T13:32:21Z
dc.date.available2020-04-30T13:32:21Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 17293657en_US
dc.description.abstractBackground/Aims: Urinary bladder dysfunction secondary to outlet obstruction is a common condition, seen in both children and adults. Using in vitro models of ischemia/reperfusion (I/R), we compared the contractile and biochemical responses of bladders isolated from young and old rabbits. Materials and Methods: Fourteen male New Zealand White rabbits were separated into two groups of 7. Group 1 (young) included rabbits 6-7 weeks old and group 2 (old) consisted of rabbits 2 years old. Isolated bladder body strips were subjected to in vitro I/R, and the effects on contractility were determined. The strips were then frozen and stored for quantitative malondialdehyde (MDA) analysis. Results: Contractile responses of young and old rabbit bladders to all forms of stimulation - field stimulation (FS), carbachol and potassium chloride (KCl) - were equal. The rate of tension to 32 Hz FS was significantly higher for group 1 in comparison with group 2. The old and young rabbits were equally sensitive to I/R in regard to FS, but the old rabbits were more sensitive to I/R in regard to carbachol and KCl stimulation. Basal MDA concentration of both young and aged bladder strips were similar. Ischemia mediated a significant increase in MDA in bladder strips from both young and old rabbits, but the MDA level was significantly greater for the young than for the old. Conclusion: Although the level of oxidative damage was greater in the young rabbit bladders, functionally, the old rabbit bladders were more sensitive to I/R damage. Copyright © 2007 S. Karger AG.en_US
dc.identifier.doi10.1159/000098075en_US
dc.identifier.endpage159en_US
dc.identifier.issn0042-1138
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000098075
dc.identifier.urihttps://hdl.handle.net/20.500.12684/252
dc.identifier.volume78en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder dysfunction; Ischemia/reperfusion; Malondialdehydeen_US
dc.titleEffect of age on the response to in vitro ischemia and reperfusion of the rabbit bladderen_US
dc.typeArticleen_US

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