Mean Platelet Volume is Associated with Glycaemic Control and Retinopathy in Patients with Type 2 Diabetes Mellitus

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dc.contributor.authorDindar, S.
dc.contributor.authorCinemre, Hakan
dc.contributor.authorŞengül, Erkan
dc.contributor.authorAnnakkaya, Ali Nihat
dc.date.accessioned2020-04-30T23:19:07Z
dc.date.available2020-04-30T23:19:07Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAnnakkaya, Ali Nihat N/0000-0002-7661-8830en_US
dc.descriptionWOS: 000333443700007en_US
dc.descriptionPubMed: 24756738en_US
dc.description.abstractObjectives: To investigate the relationship between mean platelet volume (MPV) and glycometabolic indices, to compare MPV according to HbA1c levels, and to analyse the difference in MPV between patients with and without microvascular complications. Methods: This retrospective study was conducted on 60 Type 2 diabetic patients and 50 age- and sex-matched non-diabetic controls. We obtained demographic, clinical and laboratory data including MPV platelet count, fasting and postprandial blood glucose (FBG and PBG), haemoglobin A1c (HbA1c), lipid profile, creatinine, systolic and diastolic blood pressure (BP) in patient and control groups, and diabetic microvascular complications including nephropathy, neuropathy, and retinopathy in the patient group. All analyses were performed using SPSS version 15.0 for Windows. Results: Mean platelet volume in the diabetic group was higher than in the control group (p = 0.001). Mean platelet volume was positively correlated with FBG and HbA1c levels (p = 0.03 and p < 0.001, respectively). It was also negatively related to platelet count (p < 0.001). Mean platelet volume in patients with HbA1c > 7% was significantly higher than those with HbA1c <= 7% (p < 0.001). Mean platelet volume was significantly increased in patients with retinopathy compared to those without retinopathy (p = 0.04). Conclusion: This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications.en_US
dc.identifier.endpage523en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage519en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3657
dc.identifier.volume62en_US
dc.identifier.wosWOS:000333443700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectHbA1cen_US
dc.subjectmean platelet volumeen_US
dc.subjectretinopathyen_US
dc.titleMean Platelet Volume is Associated with Glycaemic Control and Retinopathy in Patients with Type 2 Diabetes Mellitusen_US
dc.typeArticleen_US

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