Highly Active and Reusable Pd/AlO(OH) Nanoparticles for the Suzuki Cross-Coupling Reaction

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dc.contributor.authorGöksu, Haydar
dc.contributor.authorZengin, Nursefa
dc.contributor.authorKaraosman, Arife
dc.contributor.authorŞen, Fatih
dc.date.accessioned2020-05-01T12:10:22Z
dc.date.available2020-05-01T12:10:22Z
dc.date.issued2018
dc.departmentDÜ, Kaynaşlı Meslek Yüksekokuluen_US
dc.descriptionWOS: 000440087300005en_US
dc.description.abstractBackground: Biphenyl derivatives are an important component of many natural products and used in the treatment of conditions such as anxiety disorders, infections, and insomnia. In addition, the synthesis of these molecules is very important due to their kinase inhibitory effect as well as their antibacterial and antifungal effects. In this study, highly efficient and reusable Pd/AlO(OH) Nanoparticles (NPs) were used as an alternative heterogeneous catalysts system for the coupling reactions. Methods: Pd/AlO(OH) Nanoparticles (NPs) was characterized by SEM, XRD and TEM. Later, Pd/AlO(OH) nanoparticles were performed for coupling reactions. At the end of the reaction, the main products were checked with GC and the GC yield calculated. The desired biaryl products were successfully obtained within 2 h with good yields in the presence of Pd/AlO(OH) nanoparticles. Results: The morphologies of the Pd/AlO(OH) NPs were characterized by scanning electron microscopy (SEM) and x-ray diffraction (XRD). The determination of the appropriate reaction conditions for the desired biaryl products is of crucial importance for successful synthesis. For this purpose, optimization of the conditions for conversion of iodobenzene to biphenyl. was carried out in detail. The reusability of the PdAlO(OH) NPs was also examined for Suzuki Cross-Coupling Reaction. On the other hand, the high temperature and type of catalyst are the factors that make it easier to reach the activation energy. For this reason, the comparison of the designed catalytic system with recently published works are given for Suzuki cross-coupling of bromobenzene with aryl boronic acid. Last but not least, the reaction mechanism of the Suzuki cross-coupling reaction has been entirely identified in the presence of PdAlO(OH) NPs. Conclusion: A novel method was developed for the synthesis of biphenyl derivatives in a short time with high yields by the help of Pd/AlO(OH) NPs at room temperature. As starting materials, neither phenylboronic acid, nor aryl halide derivatives are water soluble, so it was desirable to conduct the reactions in water/isopropyl alcohol as an eco-friendly solvent. Thus, the developed method is both ecofriendly and economical and can be considered as a viable alternative to prior methods appearing in the literature.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2015.26.04.371]en_US
dc.description.sponsorshipThis research was supported by Duzce University Research Fund (grant no. 2015.26.04.371).en_US
dc.identifier.doi10.2174/2213337205666180614114550en_US
dc.identifier.endpage41en_US
dc.identifier.issn2213-3372
dc.identifier.issn2213-3380
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.2174/2213337205666180614114550
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6166
dc.identifier.volume5en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Organocatalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoupling reactionen_US
dc.subjecthighly efficienten_US
dc.subjectmonodisperseen_US
dc.subjectPd NPsen_US
dc.subjectbiphenyl derivativesen_US
dc.subjectheterogeneous catalystsen_US
dc.titleHighly Active and Reusable Pd/AlO(OH) Nanoparticles for the Suzuki Cross-Coupling Reactionen_US
dc.typeArticleen_US

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