Protective effect of propolis on myocardial ischemia/reperfusion injury in males and ovariectomized females but not in intact females

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dc.authoridOzarslan, Ogulcan/0000-0002-2635-7011
dc.authoridAGAN, AYDAN FULDEN/0000-0002-4319-6264
dc.authoridkaya, adnan/0000-0002-9225-8353
dc.authoridAGYAR YOLDAS, PINAR/0000-0002-9277-0648
dc.authoridKaya, Salih Tunç/0000-0002-4133-407X
dc.authorwosidOzarslan, Ogulcan/GXH-3333-2022
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorAğan, Kağan
dc.contributor.authorFulden-Ağan, Aydan
dc.contributor.authorAgyar-Yoldaş, Pınar
dc.contributor.authorÖzarslan, Talat Oğulcan
dc.contributor.authorKekeçoğlu, Meral
dc.contributor.authorKaya, Adnan
dc.date.accessioned2023-07-26T11:50:46Z
dc.date.available2023-07-26T11:50:46Z
dc.date.issued2022
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe aim of this study is to investigate the effect of propolis, which may have estrogenic effects, on myocardial ischemia/reperfusion (mI/R) injury not only in male rats but also in intact and ovariectomized (ovx) female rats. Six groups were formed: untreated males (n = 8), treated males (n = 9), untreated intact females (n = 9), treated intact females (n = 10), untreated ovx females (n = 10), and treated ovx females (n = 8). An alcoholic extract of a single dose of propolis (200 mg/kg) was administered orally daily for 14 days. Thirty minutes of ischemia and 120 min of reperfusion were performed. Blood pressure, heart rate, arrhythmias (ventricular premature contraction [VPC], ventricular tachycardia [VT], ventricular fibrillation [VF]), and myocardial infarct size were evaluated. Total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and 17 beta-estradiol (E2) were measured. The untreated females showed more resistance to mI/R injury than the untreated males, as evidenced by lower duration, incidence, and score of arrhythmias, and smaller infarct size (p < .05). After ovx, this resistance disappeared. Propolis improved these values in treated males and treated ovx females (p < .05). Propolis increased TAS in treated males and decreased TOS in treated ovx females as well as elevated SOD in all treated groups (p < .05). Propolis decreased E2 level in treated intact females; however, it increased E2 level in treated ovx females (p < .05). The results revealed that propolis could protect the heart against mI/R injury in males and ovx females. Practical applications It is known that the female heart has an increased sensitivity to myocardial ischemia/reperfusion (mI/R) injury due to estrogen deficiency and/or estrogen deprivation following menopause or surgical removal of the ovaries. Propolis has the potential to mimic estrogen under physiological and pathophysiological conditions, as well as its antioxidant property. The results indicated that propolis decreased myocardial infarct size, arrhythmia score, arrhythmia duration, and incidence in ovariectomized female rats and male rats. In addition, the present results demonstrated that an alcoholic extract of propolis as a natural product can effectively maintain the resistance of female heart to mI/R injury after estrogen deficiency.en_US
dc.description.sponsorshipDuzce University, Scientific Research Projects Fund [2018.05.01.887]en_US
dc.description.sponsorshipThis study was supported by Duzce University, Scientific Research Projects Fund (DUBAP-Project No: 2018.05.01.887).en_US
dc.identifier.doi10.1111/jfbc.14109
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue7en_US
dc.identifier.pmid35142377en_US
dc.identifier.scopus2-s2.0-85124629191en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/jfbc.14109
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12426
dc.identifier.volume46en_US
dc.identifier.wosWOS:000761958800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKaya, Salih Tunç
dc.institutionauthorKekeçoğlu, Meral
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectArrhythmia; Female; Estrogen; Infarction; Male; Propolisen_US
dc.subjectIschemia-Reperfusion Injury; Acid Phenethyl Ester; Oxidative Stress; In-Vivo; Heart; Arrhythmia; Model; Rats; Antioxidant; Ethanolen_US
dc.titleProtective effect of propolis on myocardial ischemia/reperfusion injury in males and ovariectomized females but not in intact femalesen_US
dc.typeArticleen_US

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