Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke

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dc.authoridAcar, Turkan/0000-0003-2001-914X
dc.authoridBoncuk Ulas, Sena/0000-0002-0076-9405
dc.authoridDELIBAS KATI, SENNUR/0000-0002-4619-693X
dc.authoridmemis, Zulfikar/0000-0002-5985-900X
dc.authoridAKBAS, Alihan Abdullah/0009-0005-6098-5096
dc.authoridEREN, ALPER/0000-0002-3717-5272
dc.authoridBALGETIR, FERHAT/0000-0002-6222-921X
dc.contributor.authorMemis, Zuelfikar
dc.contributor.authorGurkas, Erdem
dc.contributor.authorOzdemir, Atilla Ozcan
dc.contributor.authorAcar, Bilgehan Atilgan
dc.contributor.authorOgun, Muhammed Nur
dc.contributor.authorAytac, Emrah
dc.contributor.authorAkpinar, cetin Kuersad
dc.date.accessioned2025-10-11T20:47:48Z
dc.date.available2025-10-11T20:47:48Z
dc.date.issued2024
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: The prognostic value of the neutrophil-lymphocyte ratio (NLR) in ischemic stroke remains debated due to cohort variability and treatment heterogeneity across studies. This study evaluates the relationship between admission NLR, stroke severity and 90-day outcomes in patients with anterior circulation large vessel occlusion (LVO) undergoing early, successful revascularization. Methods: A retrospective multicenter study was conducted with 1082 patients treated with mechanical thrombectomy for acute ischemic stroke. The relationship between admission NLR, baseline National Institutes of Health Stroke Scale (NIHSS), 24 h NIHSS and 90-day modified Rankin Scale (mRS) outcomes was analyzed using logistic regression. Results: Admission NLR correlated weakly but significantly with both baseline (p = 0.018) and 24 h (p = 0.005) NIHSS scores, reflecting stroke severity. However, multivariate analysis showed that higher 24 h NIHSS scores (OR 0.831, p = 0.000) and prolonged puncture-to-recanalization times (OR 0.981, p = 0.000) were independent predictors of poor 90-day outcomes, whereas NLR was not (p = 0.557). Conclusions: Admission NLR is associated with stroke severity but does not independently predict clinical outcomes at 90 days in patients achieving early and successful revascularization. These findings underscore the critical role of inflammation in the acute phase of stroke but suggest that its prognostic value for long-term outcomes is limited in this context.en_US
dc.identifier.doi10.3390/diagnostics14242880
dc.identifier.issn2075-4418
dc.identifier.issue24en_US
dc.identifier.pmid39767241en_US
dc.identifier.scopus2-s2.0-85213300936en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/diagnostics14242880
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21581
dc.identifier.volume14en_US
dc.identifier.wosWOS:001384948500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectstrokeen_US
dc.subjectneutrophil-lymphocyte ratioen_US
dc.subjectinflammationen_US
dc.subjectprognostic biomarkersen_US
dc.subjectmechanical thrombectomyen_US
dc.titleImpact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Strokeen_US
dc.typeArticleen_US

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