THE FREQUENCY OF OMENTIN VAL109ASP POLYMORPHISM AND THE SERUM LEVEL OF OMENTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

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dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorYaykaşlı, Emine
dc.contributor.authorAtaoğlu, Safinaz
dc.contributor.authorÖzşahin, Mustafa
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorÇelebi, Esra
dc.contributor.authorYüce, Hüseyin
dc.date.accessioned2020-04-30T23:33:42Z
dc.date.available2020-04-30T23:33:42Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYaykasli, Emine/0000-0001-6471-0106; Yaykasli, Kursat/0000-0001-7550-6370en_US
dc.descriptionWOS: 000337927200033en_US
dc.description.abstractRheumatoid arthritis (RA) is an inflammatory and autoimmune disease, affecting approximately 1% population. It is characterized by irreversible destruction of articular cartilage. Omentin has been recently identified as involved in several inflammatory diseases. The aim of this study is to evaluate the potential role of omentin in pathogenesis of RA both genetic and protein levels. 87 patients who applied to Duzce University School of Medicine, Physical Medicine and Rehabilitation Clinic were included in this study. Serum omentin level and Va1109Asp genotypes were determined by Enzyme - Linked Immuno Sorbent Assay (ELISA) and Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methods respectively. There was no significant difference between patient and control groups in terms of serum omentin level and Va1109Asp polymorphism. This study is unique cause is the first study to investigate the possible role of omentin adipokine in the pathogenesis of RA in Turkish population. There was no significant relationship between omentin and RA disease. Our patients had been diagnosed previously and they started to use medicine. This can be considered to be a major limitation of our study. However, to elucidate the putative role of the omentin in the pathogenesis of RA, this study should be conducted on a larger population with more appropriate subjects.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2012.04.HD.058]en_US
dc.description.sponsorshipAcknowledgements: This project is supported by Duzce University Research Fund, Project Number 2012.04.HD.058en_US
dc.identifier.endpage526en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5028
dc.identifier.volume29en_US
dc.identifier.wosWOS:000337927200033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOmentinen_US
dc.subjectRheumatoid Artriten_US
dc.subjectPolymorphismen_US
dc.subjectELISAen_US
dc.titleTHE FREQUENCY OF OMENTIN VAL109ASP POLYMORPHISM AND THE SERUM LEVEL OF OMENTIN IN PATIENTS WITH RHEUMATOID ARTHRITISen_US
dc.typeArticleen_US

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