THE FREQUENCY OF OMENTIN VAL109ASP POLYMORPHISM AND THE SERUM LEVEL OF OMENTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Carbone Editore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease, affecting approximately 1% population. It is characterized by irreversible destruction of articular cartilage. Omentin has been recently identified as involved in several inflammatory diseases. The aim of this study is to evaluate the potential role of omentin in pathogenesis of RA both genetic and protein levels. 87 patients who applied to Duzce University School of Medicine, Physical Medicine and Rehabilitation Clinic were included in this study. Serum omentin level and Va1109Asp genotypes were determined by Enzyme - Linked Immuno Sorbent Assay (ELISA) and Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methods respectively. There was no significant difference between patient and control groups in terms of serum omentin level and Va1109Asp polymorphism. This study is unique cause is the first study to investigate the possible role of omentin adipokine in the pathogenesis of RA in Turkish population. There was no significant relationship between omentin and RA disease. Our patients had been diagnosed previously and they started to use medicine. This can be considered to be a major limitation of our study. However, to elucidate the putative role of the omentin in the pathogenesis of RA, this study should be conducted on a larger population with more appropriate subjects.
Açıklama
Yaykasli, Emine/0000-0001-6471-0106; Yaykasli, Kursat/0000-0001-7550-6370
WOS: 000337927200033
WOS: 000337927200033
Anahtar Kelimeler
Omentin, Rheumatoid Artrit, Polymorphism, ELISA
Kaynak
Acta Medica Mediterranea
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
29
Sayı
3
