The Relationship of Headache with Inflammatory Serum Parameters and Disease Severity in COVID-19 Patients
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Tarih
2020
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info:eu-repo/semantics/openAccess
Özet
Aim: Most of the coronavirus disease 2019 (COVID-19) patients have respiratory symptoms;however, various neurological symptoms, such as headache, can be seen. Thepathophysiological mechanism of headache in COVID-19 is unknown completely. In ourstudy, we aimed to investigate the relationship between headache and inflammatory markersand disease severity in COVID-19 patients.Material and Methods: Two hundred and three hospitalized patients with a polymerase chainreaction (PCR)-confirmed COVID-19 diagnosis between 15 March and 01 June 2020 wereretrospectively investigated. A total of 62 patients with headache symptoms (n=31) andwithout headache symptoms (n=31), who were age and gender-matched, were included in thestudy. The demographic characteristics, inflammatory serum parameters,neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP)/albumin ratio (CAR),hospitalization times, and disease severity were determined.Results: Of the 203 COVID-19 patients, 36 (17.7%) had a headache, and it was the fourthmost common symptom. Headache accompanied other symptoms in all patients. Of thepatients with headache, 14 (45.2%) were female, 17 (54.8%) were male, and the mean age was37.74±16.65 years. In our COVID-19 patients, the neutrophil count, NLR, CRP, CAR weresignificantly higher, and hospital stay was longer in patients with headache than those withoutheadache (p=0.023, p=0.041, p=0.034, p=0,048 and p=0.049, respectively).Conclusion: As a result, the increased inflammatory response may play a role in thepathogenesis of headache in COVID-19 patients. Our study is the first study that evaluated therelationship between headache symptom and inflammation in COVID-19 patients. Furtherresearch is needed on this subject.
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Cilt
22
Sayı
S1
