Depression and functional outcome after stroke: the effect of antidepressant therapy on functional recovery

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dc.contributor.authorBilge, C.
dc.contributor.authorKoçer, Emel
dc.contributor.authorKoçer, Abdulkadir
dc.contributor.authorBörü, Ü. Türk
dc.date.accessioned2020-05-01T09:11:18Z
dc.date.available2020-05-01T09:11:18Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKocer, Abdulkadir/0000-0003-2866-555Xen_US
dc.descriptionWOS: 000256726400003en_US
dc.descriptionPubMed: 18385623en_US
dc.description.abstractAim The optimal strategy to prevent post-stroke depression is an important but still-unresolved issue. This study examined the differences in functional recovery among post-stroke depressed patients (DP) compared to post-stroke non-depressed patients (NDP) over the course of six months after stroke. Methods. On the basis of a semistructured psychiatric examination, DSM-lV diagnostic criteria and the Hamilton Depression score, a consecutive series of ischemic or hemorrhagic stroke patients were included in this study. They had suffered from first-time stroke, and did not have depression diagnosis before. During follow-up, treatment with 20 mg/day citalopram per os was initiated whenever a diagnosis of depression was established. Their functional recoveries were assessed using the Scandinavian Stroke Scale, the modified Rankin scale and the Barthel index during acute hospitalization, at the time of depression diagnosis and at the third and sixth month follow-up visits. Results. Forty patients met the diagnostic criteria and 11 patients suffered from depression during the follow-up period. There were no differences in demographic variables, lesion characteristics and neurological symptoms between DP and NDP. Functional recovery in DP was impaired in comparison to NDP (P < 0.05). All DP, whose mood improved after administration of citalopram, and improved daily functions living functions during the follow-up. Conclusion. This study's findings suggest that remission of post-stroke depression is associated with improvement in functional recovery. Early diagnosis and effective treatment of depression will help the rehabilitation outcome of stroke patients.en_US
dc.identifier.endpage18en_US
dc.identifier.issn1973-9087
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5476
dc.identifier.volume44en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofEuropean Journal Of Physical And Rehabilitation Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectstrokeen_US
dc.subjectrecovery of functionen_US
dc.subjectdepression, therapyen_US
dc.subjectantidepressive agentsen_US
dc.subjectcitalopram, therapeutic useen_US
dc.titleDepression and functional outcome after stroke: the effect of antidepressant therapy on functional recoveryen_US
dc.typeArticleen_US

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