A multi-center, open label, crossover designed prospective study evaluating the effects of lipid lowering treatment on steroid synthesis in patients with Type 2 diabetes (MODEST Study)

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dc.contributor.authorKanat, Mustafa
dc.contributor.authorSerin, Erdinç
dc.contributor.authorTunçkale, Aydın
dc.contributor.authorYıldız, Özcan
dc.contributor.authorŞahin, Sultan
dc.contributor.authorBolayırlı, İbrahim Murat
dc.contributor.authorOğuz, Aytekin
dc.date.accessioned2020-04-30T22:38:42Z
dc.date.available2020-04-30T22:38:42Z
dc.date.issued2009
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionBOLAYIRLI, Ibrahim Murat/0000-0001-5755-7860en_US
dc.descriptionWOS: 000274444900011en_US
dc.descriptionPubMed: 19783896en_US
dc.description.abstractObjective: It has been suggested that lipid-lowering treatment with the use of statins adversely affects the steroid hormones. However, the safety of lipid lowering treatment targeting very low levels of LDL with respect to the steroid hormones has not been established. Research design and methods: A prospective, randomized, multicenter trial was conducted involving 98 patients. The patients were randomized into 2 groups: group-I received 10 mg of atorvastatin plus 10 mg of ezetimibe and group-II 80 mg of atorvastatin for the first 3 months. After crossover, the first group received 80 mg of atorvastatin and the second group 10 mg of atorvastatin plus 10 mg of ezetimibe for the following 3 months. Cortisol, DHEAS, testosterone, and estradiol levels were measured at the enrollment and at the end of the 1(st), 2(nd), 3(rd), and 6(th) months. Results: Along with a decrease in LDL level, the levels of DHEAS, testosterone, and estradiol decreased in both groups (p<0.001). While cortisol levels were maintained in the group given 10 mg of atarvastatin plus 10 mg of ezetimibe, it decreased significantly after the crossover to 80 mg of atorvastatin (p<0.001). The group initially given 80 mg of atorvastatin measured a lower level of cortisol for the first 3 months and it returned to normal levels after switching to 10 mg of atorvastatin plus 10 mg of ezetimibe. Conclusion: Eighty milligrams of atorvastatin decreased all adrenal and gonadal steroids, where,is 10 mg of ezetimibe combined with 10 mg of atorvastatin had at least no impact on cortisol levels. (J. Endocrinol. Invest. 32: 852-856, 2009) (C)2009, Editrice Kurtisen_US
dc.description.sponsorshipAbant Izzet Baysal University, TurkeyAbant Izzet Baysal University [2006/245]en_US
dc.description.sponsorshipThe study was funded by grands from Abant Izzet Baysal University, Turkey (Project Number: 2006/245).en_US
dc.identifier.doi10.1007/BF03345757en_US
dc.identifier.endpage856en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage852en_US
dc.identifier.urihttps://doi.org/10.1007/BF03345757
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2382
dc.identifier.volume32en_US
dc.identifier.wosWOS:000274444900011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtorvastatinen_US
dc.subjectlipid-lowering treatmenten_US
dc.subjectsteriod hormonesen_US
dc.subjectvery low LDLen_US
dc.titleA multi-center, open label, crossover designed prospective study evaluating the effects of lipid lowering treatment on steroid synthesis in patients with Type 2 diabetes (MODEST Study)en_US
dc.typeArticleen_US

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