Antifungal Activity of Hypericum havvae Against Some Medical Candida Yeast and Cryptococcus Species

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dc.contributor.authorDülger, Görkem
dc.contributor.authorDülger, Başaran
dc.date.accessioned2020-04-30T22:39:28Z
dc.date.available2020-04-30T22:39:28Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionDulger, Basaran/0000-0002-3184-2652; Dulger, Basaran/0000-0002-3184-2652en_US
dc.descriptionWOS: 000334491200014en_US
dc.description.abstractPurpose: To investigate the antifungal activities. of the individual as well as the combined hydroalcohol leaf and root extracts of endemic Hypericum havvae A. Guner (Hyperiaceae). Methods: Each dry powdered plant material (20 g) was soaked in 150 ml of aqueous ethanol (50: 50 % v/v) until complete saturation of the plant material. After the extracts were filtered and evaporated, the antifungal activity of the extracts was tested against medical yeast, Candida (C. albicans ATCC 10231, C. tropicalis ATCC 13808, C. guilliermondii ATCC 6260) and Cryptococcus (C. neoformans ATCC 90112 and C. laurentii 34142) species by visual broth microdilution method. Minimum inhibitory concentration (MIC) of the extract was derived from the results. Ketoconazole was used as the reference standard. Results: MIC values ranged from 3.12 to 25.00 mg/ml. The extracts exhibited strong antifungal effect against the yeast cultures but the combination of the plant extracts (leaf + root) possessed stronger antifungal potency against Candida albicans and Cryptococcus laurentii, with the same MIC value of 1.56 mg/ml. Conclusion: Our findings support the use of Hypericum havvae in traditional medicine for the treatment of fungal infections, especially Candidiasis.en_US
dc.identifier.doi10.4314/tjpr.v13i3.14en_US
dc.identifier.endpage408en_US
dc.identifier.issn1596-5996
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.4314/tjpr.v13i3.14
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2734
dc.identifier.volume13en_US
dc.identifier.wosWOS:000334491200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPharmacotherapy Groupen_US
dc.relation.ispartofTropical Journal Of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntifungal activityen_US
dc.subjectCandidaen_US
dc.subjectHypericum havvaeen_US
dc.subjectCandidiasisen_US
dc.titleAntifungal Activity of Hypericum havvae Against Some Medical Candida Yeast and Cryptococcus Speciesen_US
dc.typeArticleen_US

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