Serum IGF-1 and IGFBP-3 Levels in Healthy Children Between 0 and 6 Years of Age

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dc.contributor.authorYüksel, Bilgin
dc.contributor.authorÖzbek, M. Nuri
dc.contributor.authorMungan, Neslihan Önenli
dc.contributor.authorDarendeliler, Feyza
dc.contributor.authorBudan, Bahar
dc.contributor.authorBideci, Aysun
dc.contributor.authorErcan, Oya
dc.date.accessioned2020-04-30T23:31:52Z
dc.date.available2020-04-30T23:31:52Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionyuksel, bilgin/0000-0003-4378-3255en_US
dc.descriptionWOS: 000497376200008en_US
dc.descriptionPubMed: 21750637en_US
dc.description.abstractObjective: Along with growth hormone (GH) levels, measurements of serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) are used in the diagnosis of GH deficiency and in monitoring the efficacy and safety of long-term GH treatment. The purpose of the present study was to establish reference values for serum IGF-1 and IGFBP-3 in healthy Turkish children less than 6 years of age. Methods: This study was designed as a multicenter project. Five hundred sixty-seven healthy children younger than 6 years of age from different geographical regions of Turkey, with weight and height values between the 10th and 90th percentiles according to the national standards were included in the study. In addition to anthropometric parameters, serum IGF-1 and IGFBP-3 levels were measured in all subjects. Results: Although not statistically significant, the serum IGF-1 levels in infants at age 6 months were lower than those in infants at age 3 months. The IGF-1 levels showed a slow increase with age. Serum IGF-1 levels were lower in girls as compared to boys only at age 6 months. No correlation was found between either serum IGFBP-3 levels and body mass index (BMI) or serum IGFBP-3 and weight and height standard deviation scores (SDS). A weak correlation was observed between serum IGF-1 and IGFBP-3 concentrations. Conclusions: The age- and gender-specific reference values for serum IGF-1 and IGFBP-3 reported in this study will aid in the diagnosis of GH deficiency and in the monitoring of children receiving GH treatment.en_US
dc.identifier.doi10.4274/jcrpe.v3i2.17en_US
dc.identifier.endpage88en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.v3i2.17
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4508
dc.identifier.volume3en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of Clinical Research In Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildhooden_US
dc.subjectIGF-1en_US
dc.subjectIGFBP-3en_US
dc.subjectgrowth hormone deficiencyen_US
dc.titleSerum IGF-1 and IGFBP-3 Levels in Healthy Children Between 0 and 6 Years of Ageen_US
dc.typeArticleen_US

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