Beneficial Effect of Dexmedetomidine on Testicular Ischemia - Reperfusion Injury in Rats

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dc.contributor.authorTerzi, Hakan
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorÖztürk, Hayrettin
dc.date.accessioned2020-04-30T22:40:07Z
dc.date.available2020-04-30T22:40:07Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionBugdayci, Guler/0000-0002-4060-3354en_US
dc.descriptionWOS: 000260627800003en_US
dc.description.abstractBackground/Objectives. The present study was designed to determine the beneficial effect of dexmedetomidine (Dex) on torsion-detorsion-induced histopathological changes in experimental testicular ischemia/reperfusion (I-R) injury in rats. Material and Methods. Twenty-one male Sprague-Dawley rats were separated into three groups of seven rats each. A sham operation was performed in group 1 (control). In group 2 (I-R/Untreated), unilateral testicular torsion was performed for 6 h followed by 1 h of detorsion of the testis. In group 3 (I-R/Dex), after performing the same procedures as in group 2, dexmedetomidine was given intravenously. Ipsilateral orchidectomies were performed in all experimental rats for histological examination. The levels of MDA and activities of SOD and CAT were measured in the testicular tissue. Results. MDA levels were higher in group 2 than in group 1 rats and lower in group 3 than in group 2. SOD and CAT activities were higher in group 3 than in group 2 rats. Histopathologically, in the group 2 rats the lesions varied between grades III and IV and edema, congestion, hemorrhage between seminiferous tubules, and necrosis of the germinal cells were predominant features in sections. However, most of the specimens in the dexmedetomi-dine-treated group 3 showed grades I and II injury. The testicular injury score was also lower in group 3 rats than in group 2. Conclusions. The results show that dexmedetomidine may play a protective role in reducing injury caused by I-R (Adv Clin Exp Med 2008, 17, 5, 513-518).en_US
dc.identifier.endpage518en_US
dc.identifier.issn1899-5276
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage513en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2907
dc.identifier.volume17en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttesticular torsionen_US
dc.subjectischemia-reperfusionen_US
dc.subjectdexmedetomidineen_US
dc.subjectraten_US
dc.titleBeneficial Effect of Dexmedetomidine on Testicular Ischemia - Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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