Reproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analyses

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dc.authoridHacioglu, Ceyhan/0000-0002-0993-6118
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorKar, Fatih
dc.contributor.authorKanbak, Gungor
dc.date.accessioned2021-12-01T18:49:18Z
dc.date.available2021-12-01T18:49:18Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractAging is a natural process in which morphological and functional abnormalities in living organisms increase irreversibly. Nicotinamide (NAM) acts both as a precursor of many metabolites and as a cofactor of many enzymes involved in cell energy metabolism, homeostasis of redox balance, and regulation of signaling pathways. In this study, we investigated the effects of NAM treatment on morphological and biochemical changes in testis of old rats. The rats were treated with 200, 400, and 800 mg/kg NAM doses as a gavage for 1 month. As a result, we determined the dose-dependent therapeutic effects of NAM on testicular tissues of aged rats. We found that NAM treatment decreased total oxidant status (TOS), caspase 3 (CASP3) and cytochrome c (CYC) levels and increased total antioxidant status (TAS), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels (P<0.05). NAM treatment significantly reduced the age-related histopathological parameters such as cellular loss, necrotic tissue, interstitial edema, tubular damage, and vascular congestion in aged rat testicular tissue compared to the control group. Moreover, based on histomorphological analysis, we detected that NAM treatment resulted in a dose-dependent improvement in testicular tissue damage of old rats. Consequently, the results showed that the reproductive decline caused by aging could be ameliorated with NAM treatment.en_US
dc.identifier.doi10.1007/s43032-021-00647-7
dc.identifier.endpage3360en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85107816162en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3352en_US
dc.identifier.urihttps://doi.org/10.1007/s43032-021-00647-7
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10700
dc.identifier.volume28en_US
dc.identifier.wosWOS:000659024400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectTesticular tissueen_US
dc.subjectNicotinamideen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectCellular Senescenceen_US
dc.subjectAdenine-Dinucleotideen_US
dc.subjectBiological Theoriesen_US
dc.subjectAgeen_US
dc.subjectStressen_US
dc.subjectMitochondriaen_US
dc.subjectExpressionen_US
dc.subjectMitophagyen_US
dc.subjectRadicalsen_US
dc.subjectMarkersen_US
dc.titleReproductive Effects of Nicotinamide on Testicular Function and Structure in Old Male Rats: Oxidative, Apoptotic, Hormonal, and Morphological Analysesen_US
dc.typeArticleen_US

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