Expressions of p53, KAI1, PTEN and their use as prognostic markers in urothelial carcinoma of the bladder

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dc.contributor.authorCelik, Ozgur Ilhan
dc.contributor.authorCelik, Serkan Yasar
dc.contributor.authorHan, Unsal
dc.contributor.authorOnal, Binnur
dc.date.accessioned2021-12-01T18:49:22Z
dc.date.available2021-12-01T18:49:22Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives: To determine the expression levels of p53, KAI1, PTEN and their relations with the clinicopathologic parameters in patients with urothelial carcinoma of the bladder Design: Retrospective study Setting: Department of Pathology, Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Subjects: Seventy-eight patients with a diagnosis of urothelial carcinoma of the bladder at the Pathology Department of Ankara Diskapi Yildirim Beyazit Education and Research Hospital and who were followed up for two years Intervention: Archived pathology materials of all patients were reviewed and clinical data were collected from medical database records retrospectively. Main outcome measures: We considered the following parameters: age, gender, survivals and disease-free survivals of the patients, tumor-stage, lymphovascular-angiovascular invasions, expressions of KAI1, PTEN and p53 in tumorous tissues. Results: In non-metastatic-patients, 55.2% were p53 negative; however, 45.8% of the metastatic-patients had diffuse-strong p53-expressions. Hence, p53 positivity indicates that the tumor will metastase. In transurethral resection (TUR) materials, patients with positive KAI1-expression had better survival (p=0.0285). The tumor seemed to be more aggressive and invasive in patients with decreased KAI1-expressions because there was no KAI1 expression in 50% of the metastatic-patients, although it wasn't statistically significant (p=0.550). For PTEN expression, no statistically-significant relation was found with the tumor-stage (p=0.34) and survival/ disease-free-survival (TUR:p=0.9599/0.7576, radical cystectomy :p=0.8219/0.5790). Conclusions: The presence of metastasis dramatically decreases the overall survival in patients with urothelial carcinoma. Identification of these patients as early as possible would effect their therapies, follow-up intervals and surveys. p53 and KAI1 seem to be especially better indicators of the prognosis than PTEN.en_US
dc.identifier.endpage49en_US
dc.identifier.issn0023-5776
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85090610400en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10709
dc.identifier.volume52en_US
dc.identifier.wosWOS:000540762200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKAI1en_US
dc.subjectPTENen_US
dc.subjectp53en_US
dc.subjecturinary bladderen_US
dc.subjecturothelial carcinomaen_US
dc.subjectTransitional-Cell Carcinomaen_US
dc.subjectMolecular Markersen_US
dc.subjectSuppressor Geneen_US
dc.subjectCanceren_US
dc.subjectMetastasisen_US
dc.subjectOverexpressionen_US
dc.subjectProgressionen_US
dc.subjectRecurrenceen_US
dc.subjectCystectomyen_US
dc.subjectSeriesen_US
dc.titleExpressions of p53, KAI1, PTEN and their use as prognostic markers in urothelial carcinoma of the bladderen_US
dc.typeArticleen_US

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