Expressions of p53, KAI1, PTEN and their use as prognostic markers in urothelial carcinoma of the bladder
Yükleniyor...
Dosyalar
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kuwait Medical Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To determine the expression levels of p53, KAI1, PTEN and their relations with the clinicopathologic parameters in patients with urothelial carcinoma of the bladder Design: Retrospective study Setting: Department of Pathology, Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Subjects: Seventy-eight patients with a diagnosis of urothelial carcinoma of the bladder at the Pathology Department of Ankara Diskapi Yildirim Beyazit Education and Research Hospital and who were followed up for two years Intervention: Archived pathology materials of all patients were reviewed and clinical data were collected from medical database records retrospectively. Main outcome measures: We considered the following parameters: age, gender, survivals and disease-free survivals of the patients, tumor-stage, lymphovascular-angiovascular invasions, expressions of KAI1, PTEN and p53 in tumorous tissues. Results: In non-metastatic-patients, 55.2% were p53 negative; however, 45.8% of the metastatic-patients had diffuse-strong p53-expressions. Hence, p53 positivity indicates that the tumor will metastase. In transurethral resection (TUR) materials, patients with positive KAI1-expression had better survival (p=0.0285). The tumor seemed to be more aggressive and invasive in patients with decreased KAI1-expressions because there was no KAI1 expression in 50% of the metastatic-patients, although it wasn't statistically significant (p=0.550). For PTEN expression, no statistically-significant relation was found with the tumor-stage (p=0.34) and survival/ disease-free-survival (TUR:p=0.9599/0.7576, radical cystectomy :p=0.8219/0.5790). Conclusions: The presence of metastasis dramatically decreases the overall survival in patients with urothelial carcinoma. Identification of these patients as early as possible would effect their therapies, follow-up intervals and surveys. p53 and KAI1 seem to be especially better indicators of the prognosis than PTEN.
Açıklama
Anahtar Kelimeler
KAI1, PTEN, p53, urinary bladder, urothelial carcinoma, Transitional-Cell Carcinoma, Molecular Markers, Suppressor Gene, Cancer, Metastasis, Overexpression, Progression, Recurrence, Cystectomy, Series
Kaynak
Kuwait Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
52
Sayı
1
