Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey

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dc.authoridKuru, Burce Can/0000-0002-2286-864X
dc.authorwosidKuru, Burce Can/ABF-8954-2020
dc.contributor.authorKavala, Mukaddes
dc.contributor.authorZindanci, Ilkin
dc.contributor.authorTurkoglu, Zafer
dc.contributor.authorKuru, Burce Can
dc.contributor.authorOzlu, Emin
dc.contributor.authorSimsek, Mehmet
dc.date.accessioned2021-12-01T18:50:24Z
dc.date.available2021-12-01T18:50:24Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractIntroduction: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. Aim: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. Material and methods: The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed. Results: The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 +/- 2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 +/- 1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients. Conclusions: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis.en_US
dc.identifier.doi10.5114/ada.2020.93380
dc.identifier.endpage28en_US
dc.identifier.issn1642-395X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85082099926en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.5114/ada.2020.93380
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10871
dc.identifier.volume37en_US
dc.identifier.wosWOS:000519592400024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy Dermatologii I Alergologiien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpemphigusen_US
dc.subjecttreatmenten_US
dc.subjectmortalityen_US
dc.subjectTurkish Patientsen_US
dc.subjectVulgarisen_US
dc.subjectEpidemiologyen_US
dc.subjectFoliaceusen_US
dc.subjectRegionen_US
dc.subjectAutoantibodiesen_US
dc.subjectAssociationsen_US
dc.titleNineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkeyen_US
dc.typeArticleen_US

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