POTENTIAL GENOTOXICITY OF ACETAMIPRID AND PROPINEB SINGLY OR IN COMBINATION IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY USING MN ASSAY

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dc.contributor.authorMuranlı, Fulya Dilek Gökalp
dc.contributor.authorRasgele, Pınar Göç
dc.contributor.authorKekeçoğlu, Meral
dc.contributor.authorKanev, Martin
dc.contributor.authorÖzdemir, Kezban
dc.date.accessioned2020-04-30T23:21:11Z
dc.date.available2020-04-30T23:21:11Z
dc.date.issued2015
dc.departmentDÜ, Ziraat Fakültesi, Biyosistem Mühendisliği Bölümüen_US
dc.descriptionWOS: 000367698600008en_US
dc.description.abstractAcetamiprid, a neonicotinoid insecticide, and Propineb, a dithicarbamate fungicide, are used in agriculture singly or in combination with other pesticides. The aim of the study is to investigate the single and combined genotoxic effect two pesticides on cultured human lymphocytes by using the Micronucleus (MN) assay. The lymphocytes were treated with three different concentrations of pesticides singly and in combination (a mix), Acetamiprid (0.625, 1.25, 2.5 mu g mL(-1)) Propineb (12.5, 25, 50 mu g mL(-1)) and Acetamiprid+Propineb (0.625+12.5, 1.25+25, 2.5+50 mu g mL(-1)), for 24 and 48 hours. MN frequency significantly increased at a 48-hour exposure period when the lymphocytes were exposed to the combined pesticides. The data demonstrated that these pesticides may have a synergistic effect and may have potential genotoxic activity in cultured human lymphocytes. Also, it was shown that when they are combined and exposed to lymphocytes these pesticides have a cytotoxic effect.en_US
dc.description.sponsorshipDuzce University DUBAP projectDuzce University [2011.05.01.070]en_US
dc.description.sponsorshipThis work was supported by grants from the Duzce University DUBAP project 2011.05.01.070.en_US
dc.identifier.endpage3955en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue11Ben_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3947en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4150
dc.identifier.volume24en_US
dc.identifier.wosWOS:000367698600008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetamipriden_US
dc.subjectPropineben_US
dc.subjectin vitroen_US
dc.subjecthuman lymphocyte cultureen_US
dc.titlePOTENTIAL GENOTOXICITY OF ACETAMIPRID AND PROPINEB SINGLY OR IN COMBINATION IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES BY USING MN ASSAYen_US
dc.typeArticleen_US

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