Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery

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dc.contributor.authorGürleyik, Emin
dc.date.accessioned2020-04-30T23:31:35Z
dc.date.available2020-04-30T23:31:35Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000488108400002en_US
dc.descriptionPubMed: 31723527en_US
dc.description.abstractMarine-Lenhart syndrome (MLS), a rare form of hyperthyroidism, is the coexistence of Graves' disease (GD) and autonomously functioning thyroid nodule(s). Herein, we report a case of recurrent goiter presented with MLS. A 52-year-old man presented at our department with recurrent goiter, exophthalmia, and symptoms of hyperthyroidism. In addition to clinical signs and thyroid eye disease, suppressed thyroid-stimulating hormone (TSH) and high free thyroxine (FT4) and autoantibody levels lead to the diagnosis of GD. Thyroid ultrasound and nuclear scan showed the presence of a large, solid, and functioning "hot" nodule in the right lobe. Thus, in recurrent goiter cases, the diagnosis was MLS, wherein autoimmune hyperthyroidism was associated with the functioning nodule. Following medical control with methimazole, the patient underwent total excision of recurrent goiter. Levothyroxine (LT4) therapy was prescribed to maintain normal serum hormone levels. At follow-up, the gradual decrease in serum levels of autoantibody was detected. This patient is a very rare example of MLS that occurs in recurrent goiter case. Clinical signs, serum hormone and autoantibody levels, thyroid ultrasound, and nuclear scan establish the correct diagnosis of this specific and rare disorder. Thyroid surgery and total removal of glandular tissue provides definitive control of hyperthyroidism and obviates autoimmune reaction.en_US
dc.identifier.doi10.7759/cureus.5768
dc.identifier.issn2168-8184
dc.identifier.issue9en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.5768
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4325
dc.identifier.volume11en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCureus Incen_US
dc.relation.ispartofCureusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthyroiden_US
dc.subjecthyperthyroidismen_US
dc.subjectgraves' diseaseen_US
dc.subjectadenomaen_US
dc.subjectnoduleen_US
dc.titleRecurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgeryen_US
dc.typeArticleen_US

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